Exosome-Encased Nucleic Acid Scaffold Chemotherapeutic Agents for Superior Anti-Tumor and Anti-Angiogenesis Activity

Authors :: Ryan P. McNamara
Anthony B. Eason
Yijun Zhou
Rachele Bigi
Jack D. Griffith
Lindsey M. Costantini
Michelle A. Rudek
Nicole M. Anders
Blossom A. Damania
Dirk P. Dittmer
Source :: ACS Bio & Med Chem Au. 2:140-149
Publication Year :: 2022
Publisher :: American Chemical Society (ACS), 2022.
Abstract: Extracellular vesicles (EVs), or exosomes, play a pivotal role in tumor growth and metastasis, such as in the case of Kaposi Sarcoma. By loading tumor-derived EVs with chemotherapeutic drugs, we noted that their pro-tumor/pro-angiogenic phenotype was converted into an anti-tumor phenotype

Subjects :: Drug Discovery
Pharmaceutical Science
Molecular Biology
Biochemistry

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