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Exosome-Encased Nucleic Acid Scaffold Chemotherapeutic Agents for Superior Anti-Tumor and Anti-Angiogenesis Activity

Exosome-Encased Nucleic Acid Scaffold Chemotherapeutic Agents for Superior Anti-Tumor and Anti-Angiogenesis Activity

Authors :
Ryan P. McNamara
Anthony B. Eason
Yijun Zhou
Rachele Bigi
Jack D. Griffith
Lindsey M. Costantini
Michelle A. Rudek
Nicole M. Anders
Blossom A. Damania
Dirk P. Dittmer
Source :
ACS Bio & Med Chem Au. 2:140-149
Publication Year :
2022
Publisher :
American Chemical Society (ACS), 2022.

Abstract

Extracellular vesicles (EVs), or exosomes, play a pivotal role in tumor growth and metastasis, such as in the case of Kaposi Sarcoma. By loading tumor-derived EVs with chemotherapeutic drugs, we noted that their pro-tumor/pro-angiogenic phenotype was converted into an anti-tumor phenotype

Details

ISSN :
26942437
Volume :
2
Database :
OpenAIRE
Journal :
ACS Bio & Med Chem Au
Accession number :
edsair.doi.dedup.....d34cb7adef4de9158f22a51422971d2d
Full Text :
https://doi.org/10.1021/acsbiomedchemau.1c00030