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Glioblastoma cancer stem cell biology: Potential theranostic targets
- Source :
- Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy. 42
- Publication Year :
- 2017
-
Abstract
- Glioblastoma multiforme (GBM) is among the most incurable cancers. GBMs survival rate has not markedly improved, despite new radical surgery protocols, the introduction of new anticancer drugs, new treatment protocols, and advances in radiation techniques. The low efficacy of therapy, and short interval between remission and recurrence, could be attributed to the resistance of a small fraction of tumorigenic cells to treatment. The existence and importance of cancer stem cells (CSCs) is perceived by some as controversial. Experimental evidences suggest that the presence of therapy-resistant glioblastoma stem cells (GSCs) could explain tumor recurrence and metastasis. Some scientists, including most of the authors of this review, believe that GSCs are the driving force behind GBM relapses, whereas others however, question the existence of GSCs. Evidence has accumulated indicating that non-tumorigenic cancer cells with high heterogeneity, could undergo reprogramming and become GSCs. Hence, targeting GSCs as the "root cells" initiating malignancy has been proposed to eradicate this devastating disease. Most standard treatments fail to completely eradicate GSCs, which can then cause the recurrence of the disease. To effectively target GSCs, a comprehensive understanding of the biology of GSCs as well as the mechanisms by which these cells survive during treatment and develop into new tumor, is urgently needed. Herein, we provide an overview of the molecular features of GSCs, and elaborate how to facilitate their detection and efficient targeting for therapeutic interventions. We also discuss GBM classifications based on the molecular stem cell subtypes with a focus on potential therapeutic approaches.
- Subjects :
- 0301 basic medicine
endocrine system
Cancer Research
Antineoplastic Agents
Disease
Biology
Malignancy
Metastasis
03 medical and health sciences
0302 clinical medicine
Cancer stem cell
medicine
Humans
Pharmacology (medical)
Neoplasm Metastasis
Pharmacology
fungi
Wnt signaling pathway
medicine.disease
030104 developmental biology
Infectious Diseases
Oncology
030220 oncology & carcinogenesis
Cancer cell
Cancer research
Neoplastic Stem Cells
Stem cell
Neoplasm Recurrence, Local
Glioblastoma
Reprogramming
Subjects
Details
- ISSN :
- 15322084
- Volume :
- 42
- Database :
- OpenAIRE
- Journal :
- Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy
- Accession number :
- edsair.doi.dedup.....d35192347e6396751ec779f2a0fcd5cc