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Matrix Metalloproteinases in Diabetic Kidney Disease
- Source :
- Dipòsit Digital de Documents de la UAB, Universitat Autònoma de Barcelona, Journal of Clinical Medicine, Journal of Clinical Medicine, Vol 9, Iss 2, p 472 (2020)
- Publication Year :
- 2020
-
Abstract
- Around the world diabetic kidney disease (DKD) is the main cause of chronic kidney disease (CKD), which is characterized by mesangial expansion, glomerulosclerosis, tubular atrophy, and interstitial fibrosis. The hallmark of the pathogenesis of DKD is an increased extracellular matrix (ECM) accumulation causing thickening of the glomerular and tubular basement membranes, mesangial expansion, sclerosis, and tubulointerstitial fibrosis. The matrix metalloproteases (MMPs) family are composed of zinc-dependent enzymes involved in the degradation and hydrolysis of ECM components. Several MMPs are expressed in the kidney; nephron compartments, vasculature and connective tissue. Given their important role in DKD, several studies have been performed in patients with DKD proposing that the measurement of their activity in serum or in urine may become in the future markers of early DKD. Studies from diabetic nephropathy experimental models suggest that a balance between MMPs levels and their inhibitors is needed to maintain renal homeostasis. This review focuses in the importance of the MMPs within the kidney and their modifications at the circulation, kidney and urine in patients with DKD. We also cover the most important studies performed in experimental models of diabetes in terms of MMPs levels, renal expression and its down-regulation effect.
- Subjects :
- 0301 basic medicine
Pathology
medicine.medical_specialty
lcsh:Medicine
Nephron
Review
030204 cardiovascular system & hematology
Matrix metalloproteinase
Diabetic nephropathy
03 medical and health sciences
0302 clinical medicine
Diabetes mellitus
Tissue inhibitors of metalloproteinases
medicine
tissue inhibitors of metalloproteinases
Diabetic kidney disease
Kidney
business.industry
urogenital system
lcsh:R
Glomerulosclerosis
matrix metalloproteinases
General Medicine
medicine.disease
diabetic kidney disease
experimental models of diabetes
030104 developmental biology
medicine.anatomical_structure
Matrix metalloproteinases
Experimental models of diabetes
Tubulointerstitial fibrosis
business
Kidney disease
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Dipòsit Digital de Documents de la UAB, Universitat Autònoma de Barcelona, Journal of Clinical Medicine, Journal of Clinical Medicine, Vol 9, Iss 2, p 472 (2020)
- Accession number :
- edsair.doi.dedup.....d36059d9fead976e3488189743539bc8