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Upregulated PD-1 Expression Is Associated with the Development of Systemic Lupus Erythematosus, but Not the PD-1.1 Allele of the PDCD1 Gene
- Source :
- International Journal of Genomics, Vol 2014 (2014), International Journal of Genomics
- Publication Year :
- 2014
- Publisher :
- Hindawi Limited, 2014.
-
Abstract
- Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease with complicated genetic inheritance. Programmed death 1 (PD-1), a negative T cell regulator to maintain peripheral tolerance, induces negative signals to T cells during interaction with its ligands and is therefore a candidate gene in the development of SLE. In order to examine whether expression levels of PD-1 contribute to the pathogenesis of SLE, 30 patients with SLE and 30 controls were recruited and their PD-1 expression levels in peripheral blood mononuclear cells (PBMCs) were measured via flow cytometry and quantitative real-time-reverse transcription polymerase chain reaction (RT-PCR). Also, whether PD-1 expression levels are associated with the variant of the SNP rs36084323 and the SLE Disease Activity Index (SLEDAI) was studied in this work. The PD-1 expression levels of SLE patients were significantly increased compared with those of the healthy controls. The upregulated PD-1 expression levels in SLE patients were greatly associated with SLEDAI scores. No significant difference was found between PD-1 expression levels and SNP rs36084323. The results suggest that increased expression of PD-1 may correlate with the pathogenesis of SLE, upregulated PD-1 expression may be a biomarker for SLE diagnosis, and PD-1 inhibitor may be useful to SLE treatment.
- Subjects :
- Autoimmune disease
Candidate gene
lcsh:QH426-470
Article Subject
business.industry
T cell
Pharmaceutical Science
Peripheral tolerance
medicine.disease
Biochemistry
Peripheral blood mononuclear cell
Pathogenesis
lcsh:Genetics
medicine.anatomical_structure
immune system diseases
Immunology
Genetics
medicine
SNP
Allele
skin and connective tissue diseases
business
Molecular Biology
Research Article
Subjects
Details
- ISSN :
- 23144378 and 2314436X
- Volume :
- 2014
- Database :
- OpenAIRE
- Journal :
- International Journal of Genomics
- Accession number :
- edsair.doi.dedup.....d36cf100a26348db659499db308a20a9