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Progestogens: therapeutic and adverse effects in early post-menopausal women
- Source :
- Maturitas. 13:7-16
- Publication Year :
- 1991
- Publisher :
- Elsevier BV, 1991.
-
Abstract
- Progestogen treatment is associated with a number of subjective symptoms. In the present study, 148 healthy post-menopausal women suffering from mild climacteric symptoms were randomly allocated to 12 weeks of treatment with (a) 2 mg oestradiol valerate combined with cyproterone acetate, medroxyprogesterone acetate or levonorgestrel; (b) 1.5 mg 17 beta-oestradiol combined with desogestrel; or (c) placebo. Climacteric symptoms, Kupperman index scores and potential adverse progestogen effects were recorded before treatment and three times per month during therapy. All the hormone regimens had a rapid effect, reducing the severity of climacteric symptoms to about 30% of the baseline values (P less than 0.001) within one month. Hot flushes were reduced in severity and/or frequency by 76 100% within 3 months (P less than 0.001). The regimens which included hydroxyprogesterone derivatives produced a transient increase in breast tenderness. Other recorded potential adverse progestogen effects showed no significant changes during the study. We concluded that the addition of progestogens (whether 19-nortestosterone or hydroxyprogesterone derivatives) does not produce significant side effects during combined hormone replacement therapy.
- Subjects :
- Medroxyprogesterone
medicine.medical_specialty
medicine.medical_treatment
Physiology
Levonorgestrel
Severity of Illness Index
General Biochemistry, Genetics and Molecular Biology
chemistry.chemical_compound
Desogestrel
Internal medicine
Hormone replacement therapy (male-to-female)
Humans
Medicine
Medroxyprogesterone acetate
Cyproterone
Cyproterone Acetate
Adverse effect
Climacteric
Estradiol
Progestogen
business.industry
Norgestrel
Obstetrics and Gynecology
Cyproterone acetate
Androgen Antagonists
Middle Aged
Endocrinology
chemistry
Drug Therapy, Combination
Female
business
medicine.drug
Subjects
Details
- ISSN :
- 03785122
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Maturitas
- Accession number :
- edsair.doi.dedup.....d36faa68301b0c8a89bfad86e61761b4
- Full Text :
- https://doi.org/10.1016/0378-5122(91)90280-4