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In vivo upregulation of adipocyte alpha 2-adrenoceptors by androgens is consequence of direct action on fat cells
- Source :
- American Journal of Physiology-Cell Physiology. 267:C926-C931
- Publication Year :
- 1994
- Publisher :
- American Physiological Society, 1994.
-
Abstract
- Adipose precursor cells from male hamsters were exposed to testosterone in primary culture. The effect of the sex steroid on alpha 2-adrenoceptor (AR) expression was studied. Testosterone enhanced alpha 2-AR expression during adipose conversion to an identical extent to that determined in vivo without modification of the differentiation state as estimated by glycerol-3-phosphate dehydrogenase activity. The expression of preadipocyte alha 2-ARs from female hamster was also submitted to the testosterone control. The upregulating effect was androgen specific, since only testosterone and dihydrotestosterone were efficient in inducing an increase of alpha 2-AR density, whereas estradiol, dexamethasone, progesterone, and androstenedione were without any action. To conclude, androgens act directly on fat cells by upregulating alpha 2-AR expression. The effects are not mediated by aromatization into estrogens and probably involve androgen receptor interactions.
- Subjects :
- Male
medicine.medical_specialty
Physiology
medicine.drug_class
Alpha (ethology)
Adipose tissue
Biology
chemistry.chemical_compound
Cricetinae
Internal medicine
Adipocyte
Adipocytes
medicine
Animals
Testosterone
Dose-Response Relationship, Drug
Mesocricetus
Stem Cells
Cell Biology
Receptors, Adrenergic, alpha
Androgen
Up-Regulation
Androgen receptor
Endocrinology
chemistry
Sex steroid
Dihydrotestosterone
Androgens
Female
medicine.drug
Subjects
Details
- ISSN :
- 15221563 and 03636143
- Volume :
- 267
- Database :
- OpenAIRE
- Journal :
- American Journal of Physiology-Cell Physiology
- Accession number :
- edsair.doi.dedup.....d3951c523d6ac890d1c57e4473523908