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Long-term outcome of liver transplantation in childhood: A study of 20-year survivors
- Source :
- American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 18(7)
- Publication Year :
- 2017
-
Abstract
- We report the results of a study of survival, liver and kidney functions, and growth with a median follow-up of 24 years following liver transplantation in childhood. From 1988 to 1993, 128 children underwent deceased donor liver transplantation (median age: 2.5 years). Twenty-year patient and graft survival rates were 79% and 64%, respectively. Raised serum aminotransferase and/or γ-glutamyl transferase activities were present in 42% of survivors after a single transplantation. Graft histology (35 patients) showed signs of chronic rejection in 11 and biliary obstruction in 5. Mean total fibrosis scores were 4.5/9 and 3/9 in patients with abnormal and normal serum liver tests, respectively. Glomerular filtration rate was
- Subjects :
- Adult
Graft Rejection
Male
medicine.medical_specialty
Adolescent
medicine.medical_treatment
Renal function
030230 surgery
Liver transplantation
Kidney Function Tests
Gastroenterology
03 medical and health sciences
Young Adult
0302 clinical medicine
Postoperative Complications
Renal Dialysis
Risk Factors
Internal medicine
Immunology and Allergy
Medicine
Humans
Pharmacology (medical)
Survivors
Young adult
Child
Survival rate
Dialysis
Transplantation
business.industry
Incidence (epidemiology)
Incidence
Graft Survival
Infant
medicine.disease
Prognosis
Liver Transplantation
Survival Rate
Child, Preschool
Kidney Failure, Chronic
030211 gastroenterology & hepatology
Female
France
business
Kidney disease
Follow-Up Studies
Glomerular Filtration Rate
Subjects
Details
- ISSN :
- 16006143
- Volume :
- 18
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
- Accession number :
- edsair.doi.dedup.....d398514ffb95683dd97a71fef7001ec6