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ANMerge: A Comprehensive and Accessible Alzheimer’s Disease Patient-Level Dataset

Authors :
Sarah Westwood
Martin Hofmann-Apitius
Eric Westman
Colin Birkenbihl
Simon Lovestone
Alejo J. Nevado-Holgado
Liu Shi
Source :
Journal of Alzheimer's Disease
Publication Year :
2021
Publisher :
IOS Press, 2021.

Abstract

Background: Accessible datasets are of fundamental importance to the advancement of Alzheimer’s disease (AD) research. The AddNeuroMed consortium conducted a longitudinal observational cohort study with the aim to discover AD biomarkers. During this study, a broad selection of data modalities was measured including clinical assessments, magnetic resonance imaging, genotyping, transcriptomic profiling, and blood plasma proteomics. Some of the collected data were shared with third-party researchers. However, this data was incomplete, erroneous, and lacking in interoperability. Objective: To provide the research community with an accessible, multimodal, patient-level AD cohort dataset. Methods: We systematically addressed several limitations of the originally shared resources and provided additional unreleased data to enhance the dataset. Results: In this work, we publish and describe ANMerge, a new version of the AddNeuroMed dataset. ANMerge includes multimodal data from 1,702 study participants and is accessible to the research community via a centralized portal. Conclusion: ANMerge is an information rich patient-level data resource that can serve as a discovery and validation cohort for data-driven AD research, such as, for example, machine learning and artificial intelligence approaches.

Details

ISSN :
18758908 and 13872877
Volume :
79
Database :
OpenAIRE
Journal :
Journal of Alzheimer's Disease
Accession number :
edsair.doi.dedup.....d3b2b18b3ce9cf468e99fdc8940dd32c
Full Text :
https://doi.org/10.3233/jad-200948