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ANMerge: A Comprehensive and Accessible Alzheimer’s Disease Patient-Level Dataset
- Source :
- Journal of Alzheimer's Disease
- Publication Year :
- 2021
- Publisher :
- IOS Press, 2021.
-
Abstract
- Background: Accessible datasets are of fundamental importance to the advancement of Alzheimer’s disease (AD) research. The AddNeuroMed consortium conducted a longitudinal observational cohort study with the aim to discover AD biomarkers. During this study, a broad selection of data modalities was measured including clinical assessments, magnetic resonance imaging, genotyping, transcriptomic profiling, and blood plasma proteomics. Some of the collected data were shared with third-party researchers. However, this data was incomplete, erroneous, and lacking in interoperability. Objective: To provide the research community with an accessible, multimodal, patient-level AD cohort dataset. Methods: We systematically addressed several limitations of the originally shared resources and provided additional unreleased data to enhance the dataset. Results: In this work, we publish and describe ANMerge, a new version of the AddNeuroMed dataset. ANMerge includes multimodal data from 1,702 study participants and is accessible to the research community via a centralized portal. Conclusion: ANMerge is an information rich patient-level data resource that can serve as a discovery and validation cohort for data-driven AD research, such as, for example, machine learning and artificial intelligence approaches.
- Subjects :
- Male
Proteomics
Genotype
Computer science
Multimodal data
Interoperability
Datasets as Topic
Cohort Studies
03 medical and health sciences
0302 clinical medicine
Alzheimer Disease
medicine
Humans
dataset
Dementia
Profiling (information science)
Aged
030304 developmental biology
Aged, 80 and over
0303 health sciences
Modalities
data-driven science
Gene Expression Profiling
General Neuroscience
multimodal
biomarkers
Disease patient
General Medicine
AddNeuroMed
cohort analysis
medicine.disease
Magnetic Resonance Imaging
Data science
3. Good health
genome wide association studies
Psychiatry and Mental health
Clinical Psychology
Cohort
Female
Geriatrics and Gerontology
Alzheimer’s disease
030217 neurology & neurosurgery
Research Article
dementia
Cohort study
Subjects
Details
- ISSN :
- 18758908 and 13872877
- Volume :
- 79
- Database :
- OpenAIRE
- Journal :
- Journal of Alzheimer's Disease
- Accession number :
- edsair.doi.dedup.....d3b2b18b3ce9cf468e99fdc8940dd32c
- Full Text :
- https://doi.org/10.3233/jad-200948