Back to Search
Start Over
Pulmonary Gas Exchange and Sputum Cellular Responses to Inhaled Leukotriene D4 in Asthma
- Source :
- American Journal of Respiratory and Critical Care Medicine. 164:202-206
- Publication Year :
- 2001
- Publisher :
- American Thoracic Society, 2001.
-
Abstract
- Inhalational challenges with inflammatory mediators may provoke lung function disturbances similar to those shown in spontaneous acute asthma. Cysteinyl leukotrienes (CysLTs) have recently been established as mediators of bronchoconstriction in asthma but their effects on pulmonary gas exchange in asthma have not been assessed. We therefore investigated the effects of leukotriene D(4) (LTD(4)) challenge resulting in a significant decrease in FEV(1) (mean +/- SE, by 32 +/- 3%) in 13 nonsmoking, mild asthmatics. Respiratory system resistance (Rrs), and respiratory and inert gases were measured before and immediately after, and at 15 and 45 min after challenge. After bronchoprovocation, Rrs increased (by 106 +/- 12%), Pa(O(2)) decreased (by 25 +/- 4 mm Hg), and ventilation-perfusion distributions moderately to severely deteriorated, as shown by increases in the dispersions of pulmonary blood flow (Log SDQ, by 59 +/- 12%) and alveolar ventilation (Log SDV, by 65 +/- 20%) (p0.05 each). Sputum eosinophils (p0.05) and urinary LTE(4) (p0.005) increased after challenge. Despite the lack of mathematical correlations between spirometric and Rrs changes and gas exchange indices, the pattern of improvement of the functional variables after challenge ran in parallel. These findings support the evidence that CysLTs, in addition to being potent bronchoconstrictors, also provoke profound disturbances of pulmonary gas exchange in asthma.
- Subjects :
- Adult
Male
Pulmonary and Respiratory Medicine
medicine.medical_specialty
Leukotriene D4
Urinary system
Critical Care and Intensive Care Medicine
Gastroenterology
chemistry.chemical_compound
Internal medicine
Administration, Inhalation
medicine
Humans
Pulmonary blood flow
Respiratory system
Asthma
Pulmonary Gas Exchange
business.industry
Sputum
respiratory system
medicine.disease
respiratory tract diseases
Cysteinyl leukotrienes
chemistry
Immunology
Female
Bronchoconstriction
medicine.symptom
business
Subjects
Details
- ISSN :
- 15354970 and 1073449X
- Volume :
- 164
- Database :
- OpenAIRE
- Journal :
- American Journal of Respiratory and Critical Care Medicine
- Accession number :
- edsair.doi.dedup.....d3c0f97b9686a505248b49cff09b382c