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Prognostic Value of Focal Positive Surgical Margins After Radical Prostatectomy
- Source :
- Clinical Genitourinary Cancer. 14:e313-e319
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- Background The significance of focal positive margins (FPMs) after radical prostatectomy (RP) is unclear. Our objective was to investigate the prognostic value of FPMs in patients undergoing RP. Materials and Methods The data were analyzed retrospectively for 1733 patients with clinically localized prostate cancer who had undergone RP at our institution from December 2003 to March 2014 without neoadjuvant or adjuvant therapy. Positive surgical margins were characterized as FPMs (≤ 3 mm long) or non-FPMs (> 3 mm long). Multivariate analysis of the clinicopathologic factors, including FPMs, was performed with respect to biochemical recurrence (BCR)-free survival. Results Of the 1733 patients, 1260 (72.7%) had negative margins, 114 (6.6%) had a FPM, 218 (12.6%) had a nonfocal single positive margin (NFSPM), and 141 (8.1%) had nonfocal multiple positive margins (NFMPMs). Of the patients with pathologic T2 prostate cancer, 1065 (84.3%) had negative margins, 62 (4.9%) had 1 FPM, 104 (8.2%) had 1 NFSPM, and 33 (2.6%) had NFMPMs. The 5-year BCR-free survival for patients with negative margins and FPMs was 90% and 83.4%, respectively. On multivariate analysis, the presence of a FPM was not a significant prognostic factor for BCR-free survival in all the patients or in the patients with pathologic T2 disease (P = .458 and P = .512, respectively). Conclusions FPMs after RP do not significantly affect BCR-free survival in patients with prostate cancer.
- Subjects :
- Male
Biochemical recurrence
medicine.medical_specialty
Urology
medicine.medical_treatment
030232 urology & nephrology
Disease-Free Survival
03 medical and health sciences
Prostate cancer
0302 clinical medicine
Prostate
Adjuvant therapy
Humans
Medicine
Survival analysis
Aged
Retrospective Studies
Prostatectomy
business.industry
Margins of Excision
Prostatic Neoplasms
Retrospective cohort study
Middle Aged
Prognosis
medicine.disease
Survival Analysis
medicine.anatomical_structure
Oncology
030220 oncology & carcinogenesis
Positive Surgical Margin
business
Subjects
Details
- ISSN :
- 15587673
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Clinical Genitourinary Cancer
- Accession number :
- edsair.doi.dedup.....d3c7678552e694517da6b7b4dd68e4c4