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The effect of renal diet in association with enalapril or benazepril on proteinuria in dogs with proteinuric chronic kidney disease
- Source :
- Dipòsit Digital de Documents de la UAB, Universitat Autònoma de Barcelona, Open Veterinary Journal; Vol 6, No 2 (2016); 121-127, Open Veterinary Journal, Vol 6, Iss 2, Pp 121-127 (2016), Open Veterinary Journal
- Publication Year :
- 2016
-
Abstract
- Treating proteinuria in dogs reduces the progression of chronic kidney disease (CKD); renal diets and angiotensin -converting enzyme (ACE)-inhibitors are cornerstones of treatment. Whether different ACE-inhibitors have distinct kidney protective effects is unknown; it is therefore hypothesized that renal diets and enalapril or benazepril have different beneficial effects in proteinuric CKD dogs. Forty-four dogs with proteinuric CKD (IRIS stages 1-4) were enrolled in the study and were fed renal diet for 30 days. Thereafter, they were randomly assigned to one of 2 groups. Dogs in group A (n=22) received enalapril (0.5 mg/kg, q12h) and in group B (n=22) benazepril (0.5 mg/kg, q24h); in both groups, dogs were fed the same renal diet. After randomization, dogs were monitored for 120 days. Body weight and body condition score (BCS), serum concentrations of creatinine, blood urea nitrogen (BUN), albumin and total proteins, and urine protein-to creatinine (UPC) ratio were compared at different time-points. After 30 days of renal diet, creatinine, BUN and UPC ratio decreased significantly (p
- Subjects :
- medicine.medical_specialty
10253 Department of Small Animals
040301 veterinary sciences
3400 General Veterinary
030232 urology & nephrology
Urology
Benazepril
ACE-I, CKD, Diet, Proteinuria
Urine
urologic and male genital diseases
0403 veterinary science
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Internal medicine
medicine
ACE-I
CKD
Diet
Proteinuria
Veterinary (all)
Enalapril
Blood urea nitrogen
Creatinine
Kidney
630 Agriculture
General Veterinary
business.industry
04 agricultural and veterinary sciences
medicine.disease
female genital diseases and pregnancy complications
Endocrinology
medicine.anatomical_structure
chemistry
QL1-991
570 Life sciences
biology
Original Article
medicine.symptom
business
Zoology
medicine.drug
Kidney disease
Subjects
Details
- ISSN :
- 22186050 and 22264485
- Database :
- OpenAIRE
- Journal :
- Dipòsit Digital de Documents de la UAB, Universitat Autònoma de Barcelona, Open Veterinary Journal; Vol 6, No 2 (2016); 121-127, Open Veterinary Journal, Vol 6, Iss 2, Pp 121-127 (2016), Open Veterinary Journal
- Accession number :
- edsair.doi.dedup.....d3d519a62b42d76821f072aa88e817a8