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Coagulation abnormalities and thrombotic microangiopathy following bone marrow transplantation from HLA-matched unrelated donors in patients with hematological malignancies
- Source :
- Bone Marrow Transplantation. 21:815-819
- Publication Year :
- 1998
- Publisher :
- Springer Science and Business Media LLC, 1998.
-
Abstract
- Thrombotic microangiopathy is a well-known heterogeneous disorder that occurs as a complication of allogenic bone marrow transplantation (BMT). We evaluated 12 consecutive patients receiving HLA-matched unrelated BMT and 12 consecutive recipients of HLA-identical related BMT for the development of bone marrow transplantation-associated thrombotic microangiopathy (BMT-TM) on days 30 and 60 following BMT. A diagnosis was made in four of 12 (33.3%) unrelated compared to none of 12 (0%) HLA-identical cases. Levels of serum lactic dehydrogenase (LDH), fibrin degraded products (FDP) and de novo thrombocytopenia were elevated in eight of 12 patients (66.7%) receiving unrelated donor BMT, and none of the patients receiving related donor BMT. Our findings suggest clinical or subclinical microangiopathic changes may occur frequently in unrelated donor BMT. FDP elevation is possibly an important marker of microangiopathic changes as early complications of BMT.
- Subjects :
- Adult
Male
medicine.medical_specialty
Thrombotic microangiopathy
Adolescent
chemical and pharmacologic phenomena
Human leukocyte antigen
Gastroenterology
Fibrin
Fibrin Fibrinogen Degradation Products
immune system diseases
hemic and lymphatic diseases
Internal medicine
medicine
Humans
Bone Marrow Transplantation
Subclinical infection
Transplantation
Leukemia
biology
Vascular disease
business.industry
Thrombosis
hemic and immune systems
Hematology
Blood Coagulation Disorders
Middle Aged
medicine.disease
Tissue Donors
surgical procedures, operative
medicine.anatomical_structure
Coagulation
Immunology
biology.protein
Female
Bone marrow
Complication
business
Subjects
Details
- ISSN :
- 14765365 and 02683369
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- Bone Marrow Transplantation
- Accession number :
- edsair.doi.dedup.....d3dadb9e3e4f4882318239f562ab5d52
- Full Text :
- https://doi.org/10.1038/sj.bmt.1701169