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Plasma concentrations and therapeutic effects of budesonide in dogs with inflammatory bowel disease
- Source :
- ResearcherID
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Abstract
- Objective—To evaluate the pharmacokinetics and clinical efficacy of budesonide in dogs with inflammatory bowel disease (IBD). Animals—11 dogs (mean ± SD age, 5.7 ± 3.9 years; various breeds and body weights) with moderate or severe IBD. Procedures—Each dog received a controlled-release formulation of budesonide (3 mg/m2, PO, q 24 h) for 30 days (first day of administration was day 1). The concentration of budesonide and its metabolite (16-α-hydroxyprednisolone) was measured via liquid chromatography–tandem mass spectrometry in plasma and urine samples obtained on days 1 and 8 of treatment. On those days, plasma samples were obtained before the daily budesonide administration and 0.5, 1, 2, 4, and 7 hours after drug administration, whereas urine samples were obtained after collection of the last blood sample. A clinical evaluation was performed on the dogs before onset of drug administration and on days 20 and 30 after start of drug administration. Results—The highest plasma concentration of budesonide and 16-α-hydroxyprednisolone on day 1 was detected at 1 hour and at 2 hours after drug administration, respectively. After standardization on the basis of specific gravity, the ratio between urinary concentrations of budesonide and 16-α-hydroxyprednisolone was 0.006 and 0.012 on days 1 and 8, respectively. The clinical response was adequate in 8 of 11 dogs. Conclusions and Clinical Relevance—Budesonide was rapidly absorbed and metabolized in dogs with IBD. The drug gradually accumulated, and there was an adequate therapeutic response and no adverse effects.
- Subjects :
- Male
Budesonide
medicine.medical_specialty
Prednisolone
Metabolite
Anti-Inflammatory Agents
Administration, Oral
Urine
Pharmacology
Inflammatory bowel disease
Gastroenterology
chemistry.chemical_compound
Dogs
Pharmacokinetics
Tandem Mass Spectrometry
BUDESONIDE
Internal medicine
medicine
DOG
Animals
Dog Diseases
Clinical efficacy
Glucocorticoids
General Veterinary
business.industry
Therapeutic effect
INFLAMMATORY BOWEL DISEASE
General Medicine
Inflammatory Bowel Diseases
medicine.disease
chemistry
Plasma concentration
Female
business
Chromatography, Liquid
medicine.drug
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- ResearcherID
- Accession number :
- edsair.doi.dedup.....d3dc4d50e6d9162180e538b7dc52879f