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Detecting Immune Response to Therapies Targeting PDL1 and BRAF by Using Ferumoxytol MRI and Macrin in Anaplastic Thyroid Cancer
- Source :
- Radiology
- Publication Year :
- 2021
- Publisher :
- Radiological Society of North America (RSNA), 2021.
-
Abstract
- Background Anaplastic thyroid cancer (ATC) is aggressive with a poor prognosis, partly because of the immunosuppressive microenvironment created by tumor-associated macrophages (TAMs). Purpose To understand the relationship between TAM infiltration, tumor vascularization, and corresponding drug delivery by using ferumoxytol-enhanced MRI and macrin in an ATC mouse model. Materials and Methods ATC tumors were generated in 6-8-week-old female B6129SF1/J mice through intrathyroid injection to model orthotopic tumors, or intravenously to model hematogenous metastasis, and prospectively enrolled randomly into treatment cohorts (
- Subjects :
- Proto-Oncogene Proteins B-raf
Antineoplastic Agents
Antibodies, Monoclonal, Humanized
Thyroid Carcinoma, Anaplastic
B7-H1 Antigen
030218 nuclear medicine & medical imaging
Thyroid carcinoma
Mice
03 medical and health sciences
0302 clinical medicine
Immune system
Cell Line, Tumor
Tumor-Associated Macrophages
medicine
Animals
Radiology, Nuclear Medicine and imaging
Anaplastic thyroid cancer
Protein kinase A
biology
business.industry
Immunity
medicine.disease
Magnetic Resonance Imaging
Ferrosoferric Oxide
Immune checkpoint
Ferumoxytol
Disease Models, Animal
Reviews and Commentary
030220 oncology & carcinogenesis
Monoclonal
Cancer research
biology.protein
Nanoparticles
Female
Antibody
business
Subjects
Details
- ISSN :
- 15271315 and 00338419
- Volume :
- 298
- Database :
- OpenAIRE
- Journal :
- Radiology
- Accession number :
- edsair.doi.dedup.....d4021972bdb599ed03429f9335784b26