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Resting‐state connectivity predicts levodopa‐induced dyskinesias in Parkinson's disease
- Source :
- Movement Disorders, Herz, D M, Haagensen, B N, Nielsen, S H, Madsen, K H, Løkkegaard, A & Siebner, H R 2016, ' Resting-State Connectivity Predicts Levodopa-Induced Dyskinesias in Parkinson's Disease ', Movement Disorders, vol. 31, no. 4, pp. 521-529 . https://doi.org/10.1002/mds.26540
- Publication Year :
- 2016
- Publisher :
- John Wiley and Sons Inc., 2016.
-
Abstract
- Background Levodopa-induced dyskinesias are a common side effect of dopaminergic therapy in PD, but their neural correlates remain poorly understood. Objectives This study examines whether dyskinesias are associated with abnormal dopaminergic modulation of resting-state cortico-striatal connectivity. Methods Twelve PD patients with peak-of-dose dyskinesias and 12 patients without dyskinesias were withdrawn from dopaminergic medication. All patients received a single dose of fast-acting soluble levodopa and then underwent resting-state functional magnetic resonance imaging before any dyskinesias emerged. Levodopa-induced modulation of cortico-striatal resting-state connectivity was assessed between the putamen and the following 3 cortical regions of interest: supplementary motor area, primary sensorimotor cortex, and right inferior frontal gyrus. These functional connectivity measures were entered into a linear support vector classifier to predict whether an individual patient would develop dyskinesias after levodopa intake. Linear regression analysis was applied to test which connectivity measures would predict dyskinesia severity. Results Dopaminergic modulation of resting-state connectivity between the putamen and primary sensorimotor cortex in the most affected hemisphere predicted whether patients would develop dyskinesias with a specificity of 100% and a sensitivity of 91% (P < .0001). Modulation of resting-state connectivity between the supplementary motor area and putamen predicted interindividual differences in dyskinesia severity (R2 = 0.627, P = .004). Resting-state connectivity between the right inferior frontal gyrus and putamen neither predicted dyskinesia status nor dyskinesia severity. Conclusions The results corroborate the notion that altered dopaminergic modulation of cortico-striatal connectivity plays a key role in the pathophysiology of dyskinesias in PD. © 2016 International Parkinson and Movement Disorder Society
- Subjects :
- 0301 basic medicine
Male
Dyskinesia, Drug-Induced
Parkinson's disease
Antiparkinson Agents
Levodopa
0302 clinical medicine
Prefrontal cortex
Research Articles
Supplementary motor area
medicine.diagnostic_test
Putamen
fMRI
Parkinson Disease
Middle Aged
Prognosis
Magnetic Resonance Imaging
3. Good health
medicine.anatomical_structure
Neurology
dyskinesias
Female
Sensorimotor Cortex
medicine.symptom
Psychology
medicine.drug
Research Article
levodopa MRI
Prefrontal Cortex
03 medical and health sciences
mental disorders
medicine
otorhinolaryngologic diseases
Connectome
Humans
Aged
Dyskinesias
Resting state fMRI
Levodopa MRI
medicine.disease
nervous system diseases
030104 developmental biology
Dyskinesia
nervous system
Neurology (clinical)
Functional magnetic resonance imaging
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 15318257 and 08853185
- Volume :
- 31
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Movement Disorders
- Accession number :
- edsair.doi.dedup.....d40c79d15829af93f710b0c44e575d20