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MicroRNAs in systemic rheumatic diseases
- Source :
- Arthritis Research & Therapy
- Publication Year :
- 2011
- Publisher :
- Springer Science and Business Media LLC, 2011.
-
Abstract
- MicroRNAs (miRNAs) are endogenous, non-coding, single-stranded RNAs about 21 nucleotides in length. miRNAs have been shown to regulate gene expression and thus influence a wide range of physiological and pathological processes. Moreover, they are detected in a variety of sources, including tissues, serum, and other body fluids, such as saliva. The role of miRNAs is evident in various malignant and nonmalignant diseases, and there is accumulating evidence also for an important role of miRNAs in systemic rheumatic diseases. Abnormal expression of miRNAs has been reported in autoimmune diseases, mainly in systemic lupus erythematosus and rheumatoid arthritis. miRNAs can be aberrantly expressed even in the different stages of disease progression, allowing miRNAs to be important biomarkers, to help understand the pathogenesis of the disease, and to monitor disease activity and effects of treatment. Different groups have demonstrated a link between miRNA expression and disease activity, as in the case of renal flares in lupus patients. Moreover, miRNAs are emerging as potential targets for new therapeutic strategies of autoimmune disorders. Taken together, recent data demonstrate that miRNAs can influence mechanisms involved in the pathogenesis, relapse, and specific organ involvement of autoimmune diseases. The ultimate goal is the identification of a miRNA target or targets that could be manipulated through specific therapies, aiming at activation or inhibition of specific miRNAs responsible for the development of disease.
- Subjects :
- medicine.medical_specialty
Immunology
Review
Disease
Biology
Pathogenesis
03 medical and health sciences
0302 clinical medicine
Rheumatology
Rheumatic Diseases
Internal medicine
microRNA
Gene expression
medicine
Humans
Immunology and Allergy
Pathological
030304 developmental biology
030203 arthritis & rheumatology
0303 health sciences
Systemic lupus erythematosus
medicine.disease
3. Good health
MicroRNAs
Rheumatoid arthritis
Subjects
Details
- ISSN :
- 14786354
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Arthritis Research & Therapy
- Accession number :
- edsair.doi.dedup.....d4170cb1c0d7c4e3e17ef1401c08d161