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Pharmacometabolomics of Respiratory Phenotypic Response to Dexamethasone in Preterm Infants at Risk for Bronchopulmonary Dysplasia
- Source :
- Clinical and Translational Science, Clinical and Translational Science, Vol 12, Iss 6, Pp 591-599 (2019)
- Publication Year :
- 2019
- Publisher :
- Wiley, 2019.
-
Abstract
- A prospective cohort study was performed in preterm infants less than 32 weeks gestation at birth who were treated with dexamethasone for developing or established bronchopulmonary dysplasia (BPD). Respiratory phenotype (Respiratory Severity Score (RSS)), serum, and urine metabolomics were assessed before and after treatment. Ten infants provided nine matched serum and nine matched urine samples. There was a significant decrease in RSS with steroid treatment. Serum gluconic acid had the largest median fold change (140 times decreased, P = 0.008). In metabolite set enrichment analysis, in both serum and urine, the urea cycle, ammonia recycling, and malateāaspartate shuttle pathways were most significantly enriched when comparing pretreatment and postātreatment (P value
- Subjects :
- Male
030213 general clinical medicine
medicine.medical_specialty
Metabolite
Urine
030226 pharmacology & pharmacy
Gastroenterology
Dexamethasone
Article
General Biochemistry, Genetics and Molecular Biology
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Internal medicine
Humans
Metabolomics
Medicine
Prospective Studies
General Pharmacology, Toxicology and Pharmaceutics
Respiratory system
Prospective cohort study
Bronchopulmonary Dysplasia
business.industry
lcsh:Public aspects of medicine
Respiration
Research
General Neuroscience
lcsh:RM1-950
Infant, Newborn
Infant
lcsh:RA1-1270
Articles
General Medicine
medicine.disease
lcsh:Therapeutics. Pharmacology
Treatment Outcome
chemistry
Bronchopulmonary dysplasia
Infant, Extremely Low Birth Weight
Infant, Extremely Premature
Urea cycle
Gestation
Female
business
Biomarkers
Metabolic Networks and Pathways
medicine.drug
Subjects
Details
- ISSN :
- 17528062 and 17528054
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Clinical and Translational Science
- Accession number :
- edsair.doi.dedup.....d42602befcc43a104ca8070a11016388