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Activity-dependent regulation of inhibitory synapse development by Npas4
- Source :
- Nature. 455:1198-1204
- Publication Year :
- 2008
- Publisher :
- Springer Science and Business Media LLC, 2008.
-
Abstract
- Neuronal activity regulates the development and maturation of excitatory and inhibitory synapses in the mammalian brain. Several recent studies have identified signalling networks within neurons that control excitatory synapse development. However, less is known about the molecular mechanisms that regulate the activity-dependent development of GABA (gamma-aminobutyric acid)-releasing inhibitory synapses. Here we report the identification of a transcription factor, Npas4, that plays a role in the development of inhibitory synapses by regulating the expression of activity-dependent genes, which in turn control the number of GABA-releasing synapses that form on excitatory neurons. These findings demonstrate that the activity-dependent gene program regulates inhibitory synapse development, and suggest a new role for this program in controlling the homeostatic balance between synaptic excitation and inhibition.
- Subjects :
- Biology
Transfection
Inhibitory postsynaptic potential
Hippocampus
Article
gamma-Aminobutyric acid
Synapse
Mice
chemistry.chemical_compound
Excitatory synapse
Basic Helix-Loop-Helix Transcription Factors
medicine
Animals
Neurotransmitter
Cells, Cultured
gamma-Aminobutyric Acid
Neurons
Genetics
Multidisciplinary
Brain-Derived Neurotrophic Factor
Rats
Electrophysiology
medicine.anatomical_structure
Gene Expression Regulation
nervous system
chemistry
Synapses
Silent synapse
Excitatory postsynaptic potential
Neuron
Neuroscience
Transcription Factors
medicine.drug
Subjects
Details
- ISSN :
- 14764687 and 00280836
- Volume :
- 455
- Database :
- OpenAIRE
- Journal :
- Nature
- Accession number :
- edsair.doi.dedup.....d447e70c56527085f0aa61aacc7ad116