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A Novel .BETA.-Glucuronidase Inhibiting Triterpenoid from Paeonia emodi
- Source :
- Chemical and Pharmaceutical Bulletin. 48:1771-1773
- Publication Year :
- 2000
- Publisher :
- Pharmaceutical Society of Japan, 2000.
-
Abstract
- A novel beta-glucuronidase inhibiting triterpene (1) has been isolated from the chloroform fraction of Paeonia emodi beta-glucuronidase inhibit established ase chloroform fraction of Pa 11,beta,5alpha,23,24-pentahydroxy-30-norolean-12,20(29)-d ien-28-oic acid on the basis of spectroscopic analysis, including high resolution mass spectroscopy, one and two-dimensional NMR techniques. Oleanolic acid, betulinic acid, ethyl gallate, methyl grevillate and 1,5-dihydroxy-3-methylanthraquinone are also reported for the first time from Paeonia emodi.
- Subjects :
- Asia
Spectrophotometry, Infrared
Stereochemistry
Ethyl gallate
Spectrometry, Mass, Fast Atom Bombardment
Methylation
Paeonia emodi
chemistry.chemical_compound
Triterpenoid
Triterpene
Betulinic acid
Drug Discovery
Enzyme Inhibitors
Oleanolic acid
Glucuronidase
chemistry.chemical_classification
Plants, Medicinal
Chloroform
biology
Chemistry
Acetylation
General Chemistry
General Medicine
biology.organism_classification
Triterpenes
Subjects
Details
- ISSN :
- 13475223 and 00092363
- Volume :
- 48
- Database :
- OpenAIRE
- Journal :
- Chemical and Pharmaceutical Bulletin
- Accession number :
- edsair.doi.dedup.....d47622a676acaa65be3eae34f11c2a16
- Full Text :
- https://doi.org/10.1248/cpb.48.1771