Back to Search
Start Over
Lung disease assessment in primary ciliary dyskinesia: a comparison between chest high-field magnetic resonance imaging and high-resolution computed tomography findings
- Source :
- Italian Journal of Pediatrics, Vol 35, Iss 1, p 24 (2009), Italian Journal of Pediatrics
- Publication Year :
- 2009
- Publisher :
- BMC, 2009.
-
Abstract
- Background Primary ciliary dyskinesia (PCD) is associated with pulmonary involvement that requires periodical assessment. Chest high-resolution computed tomography (HRCT) has become the method of choice to evaluate chronic lung disease, but entails exposure to ionizing radiation. Magnetic resonance imaging (MRI) has been proposed as a potential radiation-free technique in several chest disorders. Aim of our study is to evaluate whether high-field MRI is as effective as HRCT in identifying PCD pulmonary abnormalities. We also analyzed the relationships between the severity and extension of lung disease, and functional data. Methods Thirteen PCD patients (8 children/5 adults; median age, 15.2 yrs) underwent chest HRCT and high-field 3T MRI, spirometry, and deep throat or sputum culture. Images were scored using a modified version of the Helbich system. Results HRCT and MRI total scores were 12 (range, 6–20) and 12 (range, 5–17), respectively. Agreement between HRCT and MRI scores was good or excellent (r > 0.8). HRCT and MRI total scores were significantly related to forced vital capacity (r = -0.5, p = 0.05; and r = -0.7, p = 0.009, respectively) and forced expiratory volume at 1 second (r = -0.6, p = 0.03; and r = -0.7, p = 0.009, respectively). Conclusion Chest high-field 3T MRI appears to be as effective as HRCT in assessing the extent and severity of lung abnormalities in PCD. MRI scores might be used for longitudinal assessment and be an outcome surrogate in future studies.
- Subjects :
- High-resolution computed tomography
medicine.medical_specialty
Bronchiectasis
medicine.diagnostic_test
High field magnetic resonance imaging
business.industry
Research
lcsh:RJ1-570
Magnetic resonance imaging
lcsh:Pediatrics
respiratory system
medicine.disease
Cystic fibrosis
030218 nuclear medicine & medical imaging
Chest disorders
respiratory tract diseases
03 medical and health sciences
0302 clinical medicine
030228 respiratory system
Lung disease
medicine
Radiology
business
Primary ciliary dyskinesia
Subjects
Details
- Language :
- English
- ISSN :
- 18247288 and 17208424
- Volume :
- 35
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Italian Journal of Pediatrics
- Accession number :
- edsair.doi.dedup.....d47a2e7da7e177e1aa47a1050c63cc3c