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Lipoprotein(a) has no major impact on calcification activity in patients with mild to moderate aortic valve stenosis
- Source :
- Kaiser, Y, Nurmohamed, N S, Kroon, J, Verberne, H J, Tzolos, E, Dweck, M R, Somsen, A G, Arsenault, B J, Stroes, E S G, Zheng, K H & Boekholdt, S M 2022, ' Lipoprotein(a) has no major impact on calcification activity in patients with mild to moderate aortic valve stenosis ', Heart, vol. 108, no. 1, pp. 61-66 . https://doi.org/10.1136/heartjnl-2021-319804, Heart, Kaiser, Y, Nurmohamed, N S, Kroon, J, Verberne, H J, Tzolos, E, Dweck, M R, Somsen, A G, Arsenault, B J, Stroes, E S G, Zheng, K H & Boekholdt, S M 2021, ' Lipoprotein(a) has no major impact on calcification activity in patients with mild to moderate aortic valve stenosis ', Heart, pp. heartjnl-2021-319804 . https://doi.org/10.1136/heartjnl-2021-319804, Heart, 108(1), 61-66. BMJ Publishing Group, Heart (British Cardiac Society), 108(1), 61-66. BMJ Publishing Group
- Publication Year :
- 2022
-
Abstract
- ObjectiveTo assess whether patients with aortic valve stenosis (AS) with elevated lipoprotein(a) (Lp(a)) are characterised by increased valvular calcification activity compared with those with low Lp(a).MethodsWe performed 18F-sodium fluoride (18F-NaF) positron emission tomography/CT in patients with mild to moderate AS (peak aortic jet velocity between 2 and 4 m/s) and high versus low Lp(a) (>50 mg/dL vs 18F-NaF uptake.Results52 individuals (26 matched pairs) were included in the analysis. The mean age was 66.4±5.5 years, 44 (84.6%) were men, and the mean aortic valve velocity was 2.80±0.49 m/s. The median Lp(a) was 79 (64–117) mg/dL and 7 (5–11) mg/dL in the high and low Lp(a) groups, respectively. Systolic blood pressure and low-density-lipoprotein cholesterol (corrected for Lp(a)) were significantly higher in the low Lp(a) group (141±12 mm Hg vs 128±12 mm Hg, 2.5±1.1 mmol/L vs 1.9±0.8 mmol/L). We found no difference in valvular 18F-NaF uptake between the high and low Lp(a) groups (3.02±1.26 vs 3.05±0.96, p=0.902). Linear regression analysis showed valvular calcium score to be the only significant determinant of valvular 18F-NaF uptake (β=0.63; 95% CI 0.38 to 0.88 per 1000 Agatston unit increase, p18F-NaF uptake (β=0.17; 95% CI −0.44 to 0.88, p=0.305 for the high Lp(a) group).ConclusionAmong patients with mild to moderate AS, calcification activity is predominantly determined by established calcium burden. The results do not support our hypothesis that Lp(a) is associated with valvular 18F-NaF uptake.
- Subjects :
- Aortic valve
medicine.medical_specialty
aortic valve stenosis
chemistry.chemical_compound
Internal medicine
medicine
Humans
In patient
biology
business.industry
Cholesterol
Calcinosis
Lipoprotein(a)
medicine.disease
Blood pressure
medicine.anatomical_structure
positron emission tomography computed tomography
chemistry
Aortic valve stenosis
Valvular Heart Disease
biology.protein
Cardiology
Cardiology and Cardiovascular Medicine
business
Calcification
Lipoprotein
Subjects
Details
- Language :
- English
- ISSN :
- 13556037
- Database :
- OpenAIRE
- Journal :
- Kaiser, Y, Nurmohamed, N S, Kroon, J, Verberne, H J, Tzolos, E, Dweck, M R, Somsen, A G, Arsenault, B J, Stroes, E S G, Zheng, K H & Boekholdt, S M 2022, ' Lipoprotein(a) has no major impact on calcification activity in patients with mild to moderate aortic valve stenosis ', Heart, vol. 108, no. 1, pp. 61-66 . https://doi.org/10.1136/heartjnl-2021-319804, Heart, Kaiser, Y, Nurmohamed, N S, Kroon, J, Verberne, H J, Tzolos, E, Dweck, M R, Somsen, A G, Arsenault, B J, Stroes, E S G, Zheng, K H & Boekholdt, S M 2021, ' Lipoprotein(a) has no major impact on calcification activity in patients with mild to moderate aortic valve stenosis ', Heart, pp. heartjnl-2021-319804 . https://doi.org/10.1136/heartjnl-2021-319804, Heart, 108(1), 61-66. BMJ Publishing Group, Heart (British Cardiac Society), 108(1), 61-66. BMJ Publishing Group
- Accession number :
- edsair.doi.dedup.....d47ad28662eb1d40a62e9d417a866112