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Simultaneous assessment of red blood cell aggregation and oxygen saturation under pulsatile flow using high-frequency photoacoustics
- Publication Year :
- 2022
- Publisher :
- Ryerson University Library and Archives, 2022.
-
Abstract
- We investigate the feasibility of photoacoustic (PA) imaging for assessing the correlation between red blood cell (RBC) aggregation and the oxygen saturation (sO2) in a simulated pulsatile blood flow system. For the 750 and 850 nm illuminations, the PA amplitude (PAA) increased and decreased as the mean blood flow velocity decreased and increased, respectively, at all beat rates (60, 120 and 180 bpm). The sO2 also cyclically varied, in phase with the PAA for all beat rates. However, the linear correlation between the sO2 and the PAA at 850 nm was stronger than that at 750 nm. These results suggest that the sO2 can be correlated with RBC aggregation induced by decreased mean shear rate in pulsatile flow, and that the correlation is dependent on the optical wavelength. The hemodynamic properties of blood flow assessed by PA imaging may be used to provide a new biomarker for simultaneous monitoring blood viscosity related to RBC aggregation, oxygen delivery related to the sO2 and their clinical correlation.
- Subjects :
- Chemistry
Blood viscosity
Pulsatile flow
Beat (acoustics)
Hemodynamics
Blood flow
030204 cardiovascular system & hematology
01 natural sciences
complex mixtures
Atomic and Molecular Physics, and Optics
Article
010309 optics
Shear rate
03 medical and health sciences
Red blood cell
0302 clinical medicine
Nuclear magnetic resonance
medicine.anatomical_structure
0103 physical sciences
medicine
Mean Blood Flow Velocity
Biotechnology
Biomedical engineering
Subjects
Details
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....d47b3474f1c592a237a0a76876ac0d42