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Universal Molecular Scaffold for Facile Construction of Multivalent and Multimodal Imaging Probes
- Publication Year :
- 2016
-
Abstract
- Multivalent and multimodal imaging probes are rapidly emerging as powerful chemical tools for visualizing various biochemical processes. Herein, we described a bifunctional chelator (BFC)-based scaffold that can be used to construct such promising probes concisely. Compared to other reported similar scaffolds, this new BFC scaffold demonstrated two major advantages: (1) significantly simplified synthesis due to the use of this new BFC that can serve as chelator and linker simultaneously; (2) highly efficient synthesis rendered by using either click chemistry and/or total solid-phase synthesis. In addition, the versatile utility of this molecular scaffold has been demonstrated by constructing several multivalent/multimodal imaging probes labeled with various radioisotopes, and the resulting radiotracers demonstrated substantially improved in vivo performance compared to the two individual monomeric counterparts.
- Subjects :
- Models, Molecular
Scaffold
Biomedical Engineering
Pharmaceutical Science
Bioengineering
Nanotechnology
010402 general chemistry
01 natural sciences
Multimodal Imaging
Article
Fluorescence
Mice
Animals
Pharmacology
Multimodal imaging
010405 organic chemistry
Chemistry
Extramural
Organic Chemistry
Combinatorial chemistry
0104 chemical sciences
Molecular Probes
Click chemistry
Bifunctional chelator
Molecular probe
Linker
Biotechnology
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....d49153bbafdcfdce200448bbe447735e