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Efficacy and safety of botulinum toxin type A for postoperative scar prevention and wound healing improvement: A systematic review and meta‐analysis
Efficacy and safety of botulinum toxin type A for postoperative scar prevention and wound healing improvement: A systematic review and meta‐analysis
- Source :
- Journal of Cosmetic Dermatology. 21:176-190
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- BACKGROUND Botulinum toxin type A (BTXA) has shown underlying effects for wound healing improvement. New small clinical trials keep emerging every year and updated evidence-based information is warranted. This study aimed to evaluate the efficacy and safety of BTXA for preventing scarring. METHODS Four databases were searched to recruit randomized clinical trials (RCTs) which compared the surgical wounds treated with BTXA vs. those treated with placebo or blank control. The outcomes were primarily quantified by measures including the Vancouver Scar Scale (VSS), Visual Analog Scale (VAS), Stony Brook Scar Evaluation Scales (SBSES), modified SBSES (mSBSES), and scar width. Patients' satisfaction and adverse events were also reported. RESULTS In total, 16 RCTs involving 671 cases (510 patients) were included. The outcome showed significant superiority of BTXA in VSS (mean difference [MD] = -1.32, 95% confidence interval [CI]: -2.00 to -0.65, p = 0.0001), VAS (MD = 1.29, 95% CI: 1.05-1.52, p
- Subjects :
- Wound Healing
medicine.medical_specialty
business.industry
Visual analogue scale
Surgical Wound
Surgical wound
Dermatology
Injections, Intralesional
medicine.disease
Placebo
law.invention
Clinical trial
Cicatrix
Keloid
Randomized controlled trial
law
Relative risk
Internal medicine
Humans
Medicine
Botulinum Toxins, Type A
business
Adverse effect
Subjects
Details
- ISSN :
- 14732165 and 14732130
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- Journal of Cosmetic Dermatology
- Accession number :
- edsair.doi.dedup.....d4ad46309d9d8fe3efa703b09ce7350d
- Full Text :
- https://doi.org/10.1111/jocd.14617