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Efficacy and safety of botulinum toxin type A for postoperative scar prevention and wound healing improvement: A systematic review and meta‐analysis

Efficacy and safety of botulinum toxin type A for postoperative scar prevention and wound healing improvement: A systematic review and meta‐analysis

Authors :
Hanzi Huang
Jiuzuo Huang
Ziyao Fu
Source :
Journal of Cosmetic Dermatology. 21:176-190
Publication Year :
2021
Publisher :
Wiley, 2021.

Abstract

BACKGROUND Botulinum toxin type A (BTXA) has shown underlying effects for wound healing improvement. New small clinical trials keep emerging every year and updated evidence-based information is warranted. This study aimed to evaluate the efficacy and safety of BTXA for preventing scarring. METHODS Four databases were searched to recruit randomized clinical trials (RCTs) which compared the surgical wounds treated with BTXA vs. those treated with placebo or blank control. The outcomes were primarily quantified by measures including the Vancouver Scar Scale (VSS), Visual Analog Scale (VAS), Stony Brook Scar Evaluation Scales (SBSES), modified SBSES (mSBSES), and scar width. Patients' satisfaction and adverse events were also reported. RESULTS In total, 16 RCTs involving 671 cases (510 patients) were included. The outcome showed significant superiority of BTXA in VSS (mean difference [MD] = -1.32, 95% confidence interval [CI]: -2.00 to -0.65, p = 0.0001), VAS (MD = 1.29, 95% CI: 1.05-1.52, p

Details

ISSN :
14732165 and 14732130
Volume :
21
Database :
OpenAIRE
Journal :
Journal of Cosmetic Dermatology
Accession number :
edsair.doi.dedup.....d4ad46309d9d8fe3efa703b09ce7350d
Full Text :
https://doi.org/10.1111/jocd.14617