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Towards Targeting the Aryl Hydrocarbon Receptor in Cystic Fibrosis
- Source :
- Mediators of Inflammation, Mediators of Inflammation, Vol 2018 (2018)
- Publication Year :
- 2018
-
Abstract
- Tryptophan (trp) metabolism is an important regulatory component of gut mucosal homeostasis and the microbiome. Metabolic pathways targeting the trp can lead to a myriad of metabolites, of both host and microbial origins, some of which act as endogenous low-affinity ligands for the aryl hydrocarbon receptor (AhR), a cytosolic, ligand-operated transcription factor that is involved in many biological processes, including development, cellular differentiation and proliferation, xenobiotic metabolism, and the immune response. Low-level activation of AhR by endogenous ligands is beneficial in the maintenance of immune health and intestinal homeostasis. We have defined a functional node whereby certain bacteria species contribute to host/microbial symbiosis and mucosal homeostasis. A microbial trp metabolic pathway leading to the production of indole-3-aldehyde (3-IAld) by lactobacilli provided epithelial protection while inducing antifungal resistance via the AhR/IL-22 axis. In this review, we highlight the role of AhR in inflammatory lung diseases and discuss the possible therapeutic use of AhR ligands in cystic fibrosis.
- Subjects :
- 0301 basic medicine
LUNG-DISEASE
Indoles
Cystic Fibrosis
Immunology
INNATE LYMPHOID-CELLS
Endogeny
HYPOXIA
Review Article
ACTIVATION
03 medical and health sciences
Immune system
INFLAMMATION
lcsh:Pathology
Animals
Humans
Microbiome
Receptor
Transcription factor
AH RECEPTOR
INNATE LYMPHOID-CELLS, GLYCATION END-PRODUCTS, DISEASE TOLERANCE, LUNG-DISEASE, AH RECEPTOR, INFLAMMATION, HYPOXIA, INDOLE, LIGAND, ACTIVATION
biology
Chemistry
Innate lymphoid cell
INDOLE
Cell Biology
Aryl hydrocarbon receptor
DISEASE TOLERANCE
3. Good health
Cell biology
Metabolic pathway
Lactobacillus
030104 developmental biology
Receptors, Aryl Hydrocarbon
biology.protein
LIGAND
GLYCATION END-PRODUCTS
lcsh:RB1-214
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Mediators of Inflammation, Mediators of Inflammation, Vol 2018 (2018)
- Accession number :
- edsair.doi.dedup.....d4c03d399d59c16356bf7bea6dc0dfbd