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Comprehensive evaluation of bone health using DXA and pQCT in an Indian boy with osteogenesis imperfecta
- Source :
- BMJ Case Rep
- Publication Year :
- 2020
- Publisher :
- BMJ, 2020.
-
Abstract
- We present a 9-year-old male child having history of fractures on trivial trauma with a family history of the same. He was treated for osteogenesis imperfecta (OI; zolendronate, calcium and vitamin D) and showed clinical improvement. On evaluating his bone health using dual energy X-ray absorptiometry and peripheral quantitative CT, we found that the child had bone density within the reference range but a smaller bone mass for his height, low muscle mass and thin bones with a lower strength strain index in comparison with healthy children. Our case suggests that treatment with bisphosphonates results in increase in bone density; however, bones remain thin and the lean body mass in these children may also be low. Controlled physical activity to improve muscle health and newer approaches to improve bone geometry would result in better bone health in children with OI.
- Subjects :
- Male
0301 basic medicine
Bone density
Dentistry
Case Report
030209 endocrinology & metabolism
Reference range
Zoledronic Acid
Bone health
Fractures, Bone
03 medical and health sciences
Low muscle mass
Absorptiometry, Photon
0302 clinical medicine
Bone Density
Vitamin D and neurology
Humans
Medicine
Vitamin D
Family history
Child
Bone Density Conservation Agents
Diphosphonates
business.industry
General Medicine
Osteogenesis Imperfecta
medicine.disease
030104 developmental biology
Osteogenesis imperfecta
Lean body mass
Calcium
Tomography, X-Ray Computed
business
Subjects
Details
- ISSN :
- 1757790X
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- BMJ Case Reports
- Accession number :
- edsair.doi.dedup.....d4cd42def529a12089e8d2a700a0a8a9
- Full Text :
- https://doi.org/10.1136/bcr-2020-236169