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Loss of E-cadherin promotes the growth, invasion and drug resistance of colorectal cancer cells and is associated with liver metastasis
- Source :
- Molecular biology reports. 39(6)
- Publication Year :
- 2011
-
Abstract
- The recent studies indicated that the epithelial cell adhesion molecule E-cadherin is a well-recognized molecule that is important in cell adhesion. To further investigate the molecular basis of this notion, we used small-interfering RNA to inhibit E-cadherin function and found that loss of E-cadherin promoted Colorectal cancer cell growth, invasion and drug resistance through induction of β-catenin nuclear translocation and epithelial-to-mesenchymal transition. Further analysis of E-cadherin expression with clinicopathologic parameters showed that E-cadherin expression decreased in Colorectal cancer patients who developed liver metastasis (P = 0.043). These findings indicate that E-cadherin loss in tumors contributes to progression and metastatic dissemination. Thus, E-cadherin can act as a central modulator of the cell biological phenotypes and a potential prognostic marker in Colorectal cancer.
- Subjects :
- Antimetabolites, Antineoplastic
Epithelial-Mesenchymal Transition
Deleted in Colorectal Cancer
Transcription, Genetic
Colorectal cancer
Cell Survival
Active Transport, Cell Nucleus
Biology
Mouse model of colorectal and intestinal cancer
Metastasis
chemistry.chemical_compound
Cell Movement
Genetics
medicine
Cell Adhesion
Humans
Neoplasm Invasiveness
Epithelial–mesenchymal transition
Cell adhesion
Molecular Biology
beta Catenin
Cell Proliferation
Cadherin
Liver Neoplasms
Epithelial cell adhesion molecule
General Medicine
medicine.disease
Cadherins
HCT116 Cells
Methotrexate
chemistry
Drug Resistance, Neoplasm
Gene Knockdown Techniques
Cancer research
Fluorouracil
Colorectal Neoplasms
HT29 Cells
Subjects
Details
- ISSN :
- 15734978
- Volume :
- 39
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Molecular biology reports
- Accession number :
- edsair.doi.dedup.....d4d009a34e2965ae0e1d7fd2d7d39c3d