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COVID-19 in lung transplant recipients-Risk prediction and outcomes
- Source :
- PLoS ONE, Vol 16, Iss 10, p e0257807 (2021), PLoS ONE
- Publication Year :
- 2021
- Publisher :
- Public Library of Science (PLoS), 2021.
-
Abstract
- Patients after lung transplantation are at risk for life-threatening infections. Recently, several publications on COVID-19 outcomes in this patient population appeared, but knowledge on optimal treatment, mortality, outcomes, and appropriate risk predictors is limited. A retrospective analysis was performed in a German high-volume lung transplant center between 19th March 2020 and 18th May 2021. Impact of COVID-19 on physical and psychological health, clinical outcomes, and mortality were analyzed including follow-up visits up to 12 weeks after infection in survivors. Predictive parameters on survival were assessed using univariate and multivariate proportional hazards regression models. Out of 1,046 patients in follow-up, 31 acquired COVID-19 during the pandemic. 12 of 31 (39%) died and 26 (84%) were hospitalized. In survivors a significant decline in exercise capacity (p = 0.034), TLC (p = 0.02), and DLCO (p = 0.007) was observed at follow-up after 3 months. Anxiety, depression, and self-assessed quality of life remained stable. Charlson comorbidity index predicted mortality (HR 1.5, 1.1–2.2; p = 0.023). In recipients with pre-existing CLAD, mortality and clinical outcomes were inferior. However, pre-existing CLAD did not predict mortality. COVID-19 remains a life-threatening disease for lung transplant recipients, particularly in case comorbidities. Further studies on long term outcomes and impact on pre-existing CLAD are needed.
- Subjects :
- RNA viruses
Male
Viral Diseases
Pulmonology
Coronaviruses
Epidemiology
medicine.medical_treatment
Disease
Medical Conditions
Quality of life
DLCO
Medicine and Health Sciences
Respiratory System Procedures
Depression (differential diagnoses)
Pathology and laboratory medicine
Multidisciplinary
Medical microbiology
Middle Aged
Exercise Therapy
Hospitalization
Chemistry
Infectious Diseases
Viruses
Physical Sciences
Anxiety
Medicine
Female
medicine.symptom
SARS CoV 2
Pathogens
Risk assessment
Research Article
Lung Transplantation
Chemical Elements
Adult
medicine.medical_specialty
SARS coronavirus
Death Rates
Science
Surgical and Invasive Medical Procedures
Microbiology
Risk Assessment
Respiratory Disorders
Population Metrics
Complementary and Alternative Medicine
Internal medicine
medicine
Lung transplantation
Humans
Retrospective Studies
Transplantation
Biology and life sciences
Population Biology
business.industry
Organisms
Viral pathogens
COVID-19
Retrospective cohort study
Covid 19
Organ Transplantation
Transplant Recipients
Microbial pathogens
Oxygen
Medical Risk Factors
Respiratory Infections
Quality of Life
business
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 16
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....d4d2c72e793fa51283527d327e9668d6