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Osteogenic and Neurogenic Stem Cells in Their Own Place: Unraveling Differences and Similarities Between Niches
- Source :
- Frontiers in Cellular Neuroscience, Frontiers in Cellular Neuroscience, Vol 9 (2015)
- Publication Year :
- 2015
- Publisher :
- Frontiers Media SA, 2015.
-
Abstract
- Although therapeutic use of stem cells (SCs) is already available in some tissues (cornea, blood, and skin), in most organs we are far from reaching the translational goal of regenerative medicine. In the nervous system, due to intrinsic features which make it refractory to regeneration/repair, it is very hard to obtain functionally integrated regenerative outcomes, even starting from its own SCs (the neural stem cells; NSCs). Besides NSCs, mesenchymal stem cells (MSCs) have also been proposed for therapeutic purposes in neurological diseases. Yet, direct (regenerative) and indirect (bystander) effects are often confused, as are MSCs and bone marrow-derived (stromal, osteogenic) stem cells (BMSCs), whose plasticity is actually overestimated (i.e., trans-differentiation along non-mesodermal lineages, including neural fates). In order to better understand failure in the “regenerative” use of SCs for neurological disorders, it could be helpful to understand how NSCs and BMSCs have adapted to their respective organ niches. In this perspective, here the adult osteogenic and neurogenic niches are considered and compared within their in vivo environment.
- Subjects :
- Mini Review
Clinical uses of mesenchymal stem cells
Regenerative Medicine
Regenerative medicine
lcsh:RC321-571
osteogenesis
Cellular and Molecular Neuroscience
adult neurogenesis
brain repair
mesenchymal stem cells
neural stem cells
neurodegenerative diseases
Medicine
brain repair, neurodegenerative diseases, neural stem cells, mesenchymal stem cells, adult neurogenesis, osteogenesis
lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry
Stem cell transplantation for articular cartilage repair
Settore BIO/16 - ANATOMIA UMANA
business.industry
Regeneration (biology)
Neurogenesis
Mesenchymal stem cell
Neural stem cell
nervous system
cell therapy
Stem cell
business
Neuroscience
Subjects
Details
- ISSN :
- 16625102
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Frontiers in Cellular Neuroscience
- Accession number :
- edsair.doi.dedup.....d4e18db833e56a0324cd1eb15fe40118