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Innovative Biomaterials Based on Collagen-Hydroxyapatite and Doxycycline for Bone Regeneration
- Source :
- Advances in Materials Science and Engineering, Vol 2016 (2016)
- Publication Year :
- 2016
- Publisher :
- Hindawi Publishing Corporation, 2016.
-
Abstract
- Bone regeneration is a serious challenge in orthopedic applications because of bone infections increase, tumor developing, and bone loss due to trauma. In this context, the aim of our study was to develop innovative biomaterials based on collagen and hydroxyapatite (25, 50, and 75%) which mimic bone composition and prevent or treat infections due to doxycycline content. The biomaterials were obtained by freeze-drying in spongious forms and were characterized by water uptake capacity and microscopy. Thein vitrorelease of doxycycline was also determined and established by non-Fickian drug transport mechanism. Among the studied biomaterials, the most suitable one to easily deliver the drug and mimic bone structure, having compact structure and lower capacity to uptake water, was the one with 75% hydroxyapatite and being cross-linked.
- Subjects :
- Doxycycline
Materials science
Article Subject
General Engineering
Context (language use)
02 engineering and technology
010402 general chemistry
021001 nanoscience & nanotechnology
01 natural sciences
0104 chemical sciences
Bone Infection
Water uptake
lcsh:TA401-492
medicine
lcsh:Materials of engineering and construction. Mechanics of materials
General Materials Science
0210 nano-technology
Bone regeneration
Bone structure
Drug transport
Biomedical engineering
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 16878434
- Database :
- OpenAIRE
- Journal :
- Advances in Materials Science and Engineering
- Accession number :
- edsair.doi.dedup.....d4e48de589b929a5a27fbf6a94a3f55b
- Full Text :
- https://doi.org/10.1155/2016/3452171