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The ubiquitin-like modifier FAT10 in cancer development
- Publication Year :
- 2016
-
Abstract
- During the last years it has emerged that the ubiquitin-like modifier FAT10 is directly involved in cancer development. FAT10 expression is highly up-regulated by proinflammatory cytokines IFN-γ and TNF-α in all cell types and tissues and it was also found to be upregulated in many cancer types such as glioma, colorectal, liver or gastric cancer. While proinflammatory cytokines within the tumor microenvironment probably contribute to FAT10 overexpression, an increasing body of evidence argues that pro-malignant capacities of FAT10 itself largely underlie its broad and intense overexpression in tumor tissues. FAT10 thereby regulates pathways involved in cancer development such as the NF-κB- or Wnt-signaling. Moreover, FAT10 directly interacts with and influences downstream targets such as p53 or β-catenin, leading to enhanced survival, proliferation, invasion and metastasis formation of cancer cells but also of non-malignant cells. In this review we will provide an overview of the regulation of FAT10 expression as well as its function in carcinogenesis. published
- Subjects :
- 0301 basic medicine
Cell type
Carcinogenesis
Biology
medicine.disease_cause
Biochemistry
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Neoplasms
ddc:570
medicine
Animals
Humans
Ubiquitins
Tumor microenvironment
Cancer
NF-κB
Cell Biology
medicine.disease
Gene Expression Regulation, Neoplastic
030104 developmental biology
chemistry
Proteasome
030220 oncology & carcinogenesis
Immunology
Cancer cell
Cancer research
Tumor necrosis factor alpha
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....d4f08f1bdf555210c3fe6b49d2ccf0b7