Back to Search
Start Over
Maternal mild thyroid dysfunction and offspring cognitive and motor development from infancy to childhood: the Rhea mother-child cohort study in Crete, Greece
Maternal mild thyroid dysfunction and offspring cognitive and motor development from infancy to childhood: the Rhea mother-child cohort study in Crete, Greece
- Source :
- Journal of Epidemiology and Community Health, 75(1), 29-35. BMJ Publishing Group, J Epidemiol Community Health
- Publication Year :
- 2021
-
Abstract
- BackgroundMaternal thyroid hormones’ supply is crucial for fetal neurodevelopment; however, the role of maternal mild thyroid dysfunction is not clear. We aimed to assess the association of maternal mild thyroid dysfunction with child neuropsychological development from infancy to early childhood.MethodsWe included 757 mother–child pairs from the prospective ‘Rhea’ cohort on Crete, Greece. Maternal thyroid functioning was assessed by quantitative analysis of serum thyroid-stimulating hormone, free thyroxine, thyroid peroxidase antibodies and thyroglobulin antibodies at early gestation (mean=14 weeks). Neuropsychological assessment was based on Bayley Scales of Infant Development (18 months of age), McCarthy Scales of Children’s Abilities (4 years of age), Raven’s Coloured Progressive Matrices, Trail Making Test and Finger Tapping Test (6 years of age).ResultsIn multivariate adjusted linear regression analyses, maternal hypothyroxinemia was associated with decreased verbal scores at 4 years and reduced motor speed at 6 years of age. Maternal thyroid autoimmunity was associated with decreased child perceptual and motor ability at 4 years of age. Four trajectories of longitudinal non-verbal cognitive development were identified and children exposed to maternal thyroid autoimmunity had increased risk for belonging to an adverse trajectory (‘low’: adjusted relative risk ratio (RRR) = 2.7 95% CI: (1.4, 5.2), ‘high-decreasing’: adjusted RRR = 2.2 95% CI: (1.2, 4.0), ‘low-increasing’: adjusted RRR = 1.8 95% CI: (1.0, 3.2)).ConclusionMaternal hypothyroxinemia is associated with reduced offspring verbal and motor ability. Maternal thyroid autoimmunity is associated with decreased offspring perceptual performance and motor ability and increased risk for adverse non-verbal cognitive development from infancy to childhood.
- Subjects :
- cognition
Pediatrics
Epidemiology
diagnosis
medicine.medical_treatment
AUTOIMMUNITY
Rheiformes
Trail Making Test
Thyroid Gland
Bayley Scales of Infant Development
Child Development
0302 clinical medicine
born
cohort studies
Pregnancy
Prospective Studies
030212 general & internal medicine
Greece
biology
Thyroid
Mother-Child Relations
medicine.anatomical_structure
Child, Preschool
Prenatal Exposure Delayed Effects
Female
Cohort study
endocrine system
medicine.medical_specialty
hypothyroxinemia
brain morphology
Offspring
030209 endocrinology & metabolism
Article
NEURODEVELOPMENT
03 medical and health sciences
Thyroid peroxidase
medicine
Animals
Humans
hormones
business.industry
Infant, Newborn
Public Health, Environmental and Occupational Health
association
Infant
medicine.disease
IQ
HYPOTHYROIDISM
biology.protein
Thyroglobulin
early-pregnancy
business
Subjects
Details
- Language :
- English
- ISSN :
- 0143005X
- Database :
- OpenAIRE
- Journal :
- Journal of Epidemiology and Community Health, 75(1), 29-35. BMJ Publishing Group, J Epidemiol Community Health
- Accession number :
- edsair.doi.dedup.....d4f2ffba154a839ff243c1bf67fea71e