Nasal sensitivity to vasoconstrictors

MEDICAL literature contains many examples of pathologic conditions arising from the use of drugs given for the relief of various diseases or symptoms. One of the earliest examples is that represented in the symptoms due to withdrawal of cocaine, a drug which was not at first known to be habit forming. Many doctors themselves became addicted to its use. Two striking examples in recent years of pathologic states arising from the action of drugs are cataract formation from the use of dinitrophenol and granulocytopenia from the use of aminopyrine. Aminopyrine had come into wide use several years prior to the reports of a strange new disease, termed "agranulocytosis." A causal connection with the drug was not discovered until some years later. Dinitrophenol was used for reducing weight for some time before it was recognized to be a cause of cataracts. In medical literature there are many other instances of the