Oxidative Stress in Post-Acute Ischemic Stroke Patients: Relevance of Early Intensive Neurorehabilitation

Oxidative stress was investigated in 10 post-acute stroke patients (median age 76.40 ± 2.09 years) assigned to in-hospital neurorehabilitation within 7 days of onset of a first-ever ischemic stroke. Assessments were made before and after neurorehabilitation. Outcome measures were the National Institutes of Health Stroke Scale (NIHSS), the Barthel Index (BI), the Katz Index (KI), the modified Rankin Scale (mRS) and the modified PULSES profile. Differences between scores evaluated before and after neurorehabilitation were expressed as Δ scores. Oxidative stress was assessed by measuring plasma amount of total peroxides by-products, nitrite/nitrate metabolites (NOx), total plasma antioxidant capacity (TEAC), Cu/Zn Superoxide Dismutase (Cu/ZnSOD), and serum urate concentration. Ten healthy volunteers (median age 74.30 ± 3.03 years) were recruited as controls for comparison of oxidative markers. Neurorehabilitation was associated with an improvement (P