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Blood pressure and risk of cancer in the European Prospective Investigation into Cancer and Nutrition
- Source :
- Christakoudi, S, Kakourou, A, Markozannes, G, Tzoulaki, I, Weiderpass, E, Brennan, P, Gunter, M, Dahm, C C, Overvad, K, Olsen, A, Tjønneland, A, Boutron-Ruault, M-C, Madika, A-L, Severi, G, Katzke, V, Kühn, T, Bergmann, M M, Boeing, H, Karakatsani, A, Martimianaki, G, Thriskos, P, Masala, G, Sieri, S, Panico, S, Tumino, R, Ricceri, F, Agudo, A, Redondo-Sánchez, D, Colorado-Yohar, S M, Mokoroa, O, Melander, O, Stocks, T, Häggström, C, Harlid, S, Bueno-de-Mesquita, B, van Gils, C H, Vermeulen, R C H, Khaw, K-T, Wareham, N J, Tong, T Y N, Freisling, H, Johansson, M, Lennon, H, Aune, D, Riboli, E, Trichopoulos, D, Trichopoulou, A & Tsilidis, K K 2020, ' Blood pressure and risk of cancer in the European Prospective Investigation into Cancer and Nutrition ', International Journal of Cancer, vol. 146, no. 10, pp. 2680-2693 . https://doi.org/10.1002/ijc.32576, International Journal of Cancer, 146(10), 2680. Wiley-Liss Inc., Int J Cancer
- Publication Year :
- 2020
-
Abstract
- Several studies have reported associations of hypertension with cancer, but not all results were conclusive. We examined the association of systolic (SBP) and diastolic (DBP) blood pressure with the development of incident cancer at all anatomical sites in the European Prospective Investigation into Cancer and Nutrition (EPIC). Hazard ratios (HRs) (95% confidence intervals) were estimated using multivariable Cox proportional hazards models, stratified by EPIC-participating center and age at recruitment, and adjusted for sex, education, smoking, body mass index, physical activity, diabetes and dietary (in women also reproductive) factors. The study included 307,318 men and women, with an average follow-up of 13.7 (standard deviation 4.4) years and 39,298 incident cancers. We confirmed the expected positive association with renal cell carcinoma: HR = 1.12 (1.08-1.17) per 10 mm Hg higher SBP and HR = 1.23 (1.14-1.32) for DBP. We additionally found positive associations for esophageal squamous cell carcinoma (SCC): HR = 1.16 (1.07-1.26) (SBP), HR = 1.31 (1.13-1.51) (DBP), weaker for head and neck cancers: HR = 1.08 (1.04-1.12) (SBP), HR = 1.09 (1.01-1.17) (DBP) and, similarly, for skin SCC, colon cancer, postmenopausal breast cancer and uterine adenocarcinoma (AC), but not for esophageal AC, lung SCC, lung AC or uterine endometroid cancer. We observed weak inverse associations of SBP with cervical SCC: HR = 0.91 (0.82-1.00) and lymphomas: HR = 0.97 (0.93-1.00). There were no consistent associations with cancers in other locations. Our results are largely compatible with published studies and support weak associations of blood pressure with cancers in specific locations and morphologies.
- Subjects :
- Male
Cancer Research
association
cancer
cohort
epidemiology
Europe
hypertension
morphology
risk factors
Adult
Aged
Blood Pressure
Cohort Studies
Diet
Female
Humans
Hypertension
Incidence
Middle Aged
Neoplasms
Nutrition Assessment
Risk Factors
Colorectal cancer
THERAPY
COLORECTAL-CANCER
0302 clinical medicine
RENAL-CELL CARCINOMA
METABOLIC SYNDROME
BODY-SIZE
European Prospective Investigation into Cancer and Nutrition
Oncology
030220 oncology & carcinogenesis
Life Sciences & Biomedicine
circulatory and respiratory physiology
Cohort study
medicine.medical_specialty
macromolecular substances
Article
03 medical and health sciences
Breast cancer
Internal medicine
medicine
BREAST-CANCER
1112 Oncology and Carcinogenesis
cardiovascular diseases
Oncology & Carcinogenesis
Science & Technology
business.industry
INCIDENT HYPERTENSION
Endometrial cancer
Cancer
ENDOMETRIAL CANCER
medicine.disease
Blood pressure
CIGARETTE-SMOKING
Metabolic syndrome
business
Subjects
Details
- Language :
- English
- ISSN :
- 00207136
- Database :
- OpenAIRE
- Journal :
- Christakoudi, S, Kakourou, A, Markozannes, G, Tzoulaki, I, Weiderpass, E, Brennan, P, Gunter, M, Dahm, C C, Overvad, K, Olsen, A, Tjønneland, A, Boutron-Ruault, M-C, Madika, A-L, Severi, G, Katzke, V, Kühn, T, Bergmann, M M, Boeing, H, Karakatsani, A, Martimianaki, G, Thriskos, P, Masala, G, Sieri, S, Panico, S, Tumino, R, Ricceri, F, Agudo, A, Redondo-Sánchez, D, Colorado-Yohar, S M, Mokoroa, O, Melander, O, Stocks, T, Häggström, C, Harlid, S, Bueno-de-Mesquita, B, van Gils, C H, Vermeulen, R C H, Khaw, K-T, Wareham, N J, Tong, T Y N, Freisling, H, Johansson, M, Lennon, H, Aune, D, Riboli, E, Trichopoulos, D, Trichopoulou, A & Tsilidis, K K 2020, ' Blood pressure and risk of cancer in the European Prospective Investigation into Cancer and Nutrition ', International Journal of Cancer, vol. 146, no. 10, pp. 2680-2693 . https://doi.org/10.1002/ijc.32576, International Journal of Cancer, 146(10), 2680. Wiley-Liss Inc., Int J Cancer
- Accession number :
- edsair.doi.dedup.....d51b1dde9f8dd771166d4ca2f1b1732b