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Adult onset asthma and interaction between genes and active tobacco smoking: The GABRIEL consortium
- Source :
- PLoS ONE, 12(3):e0172716. PUBLIC LIBRARY SCIENCE, PLoS ONE, Vol 12, Iss 3, p e0172716 (2017), PLoS ONE, PLoS ONE 12:e0172716 (2017)
- Publication Year :
- 2017
- Publisher :
- Public Library of Science (PLoS), 2017.
-
Abstract
- BACKGROUND: Genome-wide association studies have identified novel genetic associations for asthma, but without taking into account the role of active tobacco smoking. This study aimed to identify novel genes that interact with ever active tobacco smoking in adult onset asthma.METHODS: We performed a genome-wide interaction analysis in six studies participating in the GABRIEL consortium following two meta-analyses approaches based on 1) the overall interaction effect and 2) the genetic effect in subjects with and without smoking exposure. We performed a discovery meta-analysis including 4,057 subjects of European descent and replicated our findings in an independent cohort (LifeLines Cohort Study), including 12,475 subjects.RESULTS: First approach: 50 SNPs were selected based on an overall interaction effect at pCONCLUSIONS: Using two genome-wide interaction approaches, we identified novel polymorphisms in non-annotated intergenic regions on chromosomes 9 and 12, that showed suggestive evidence for interaction with active tobacco smoking in the onset of adult asthma.
- Subjects :
- 0301 basic medicine
Oncology
Pulmonology
lcsh:Medicine
Genome-wide association study
WHOLE-GENOME ASSOCIATION
Cohort Studies
Habits
Mathematical and Statistical Techniques
Smoking Habits
Medicine and Health Sciences
Public and Occupational Health
Gene–environment interaction
lcsh:Science
Genetics
HUMAN-DISEASES
Multidisciplinary
Chromosome Biology
LARGE-SCALE
Smoking
3. Good health
Multidisciplinary Sciences
ENVIRONMENT INTERACTION
Research Design
EGEA
Cohort
Physical Sciences
Science & Technology - Other Topics
Statistics (Mathematics)
Cohort study
Research Article
Adult
medicine.medical_specialty
Substance-Related Disorders
General Science & Technology
Replication Studies
Single-nucleotide polymorphism
Research and Analysis Methods
Polymorphism, Single Nucleotide
Chromosomes
03 medical and health sciences
Internal medicine
Mental Health and Psychiatry
MD Multidisciplinary
medicine
Adults
Humans
Genetic Predisposition to Disease
EXPOSURE
Statistical Methods
Chromosome 12
Genetic association
Asthma
Chromosome 9
Behavior
DECLINE
Science & Technology
business.industry
lcsh:R
Biology and Life Sciences
Smoking Related Disorders
CHILDHOOD ASTHMA
Cell Biology
medicine.disease
Chromosome Pairs
030104 developmental biology
Age Groups
People and Places
Population Groupings
lcsh:Q
Gene-Environment Interaction
business
Mathematics
Meta-Analysis
Genome-Wide Association Study
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Database :
- OpenAIRE
- Journal :
- PLoS ONE, 12(3):e0172716. PUBLIC LIBRARY SCIENCE, PLoS ONE, Vol 12, Iss 3, p e0172716 (2017), PLoS ONE, PLoS ONE 12:e0172716 (2017)
- Accession number :
- edsair.doi.dedup.....d521c3a49a78a1234f399baa801d27c7