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Prognosis of Patients with Cutaneous Angiosarcoma After Surgical Resection with Curative Intent

Prognosis of Patients with Cutaneous Angiosarcoma After Surgical Resection with Curative Intent

Authors :
Sophie J. M. Reijers
Eva A. Huis in ’t Veld
Dirk J. Grünhagen
Myles J. F. Smith
Tessa M. van Ginhoven
Frits van Coevorden
Winette T. A. van der Graaf
Yvonne Schrage
Dirk C. Strauss
Rick L. M. Haas
Cornelis J. Verhoef
Andrew J. Hayes
Winan J. van Houdt
Dermatology
Surgery
Medical Oncology
Source :
Annals of Surgical Oncology, 30(1), 493-502. Springer New York
Publication Year :
2023

Abstract

BACKGROUND: The etiology of cutaneous angiosarcoma (cAS) may be idiopathic (I-cAS), or arise secondary to radiotherapy (RT-cAS), in chronic lymphedema (ST-cAS), or related to UV exposure (UV-cAS). The aim of this study was to evaluate oncological outcomes of different cAS subtypes.PATIENTS AND METHODS: Non-metastatic cAS patients, treated with surgery for primary disease with curative intent, were retrospectively analyzed for oncological outcome, including local recurrence (LR), distant metastases (DM), and overall survival (OS).RESULTS: A total of 234 patients were identified; 60 I-cAS, 122 RT-cAS, 9 ST-cAS, and 43 UV-cAS. The majority was female (78%), the median age was 66 years (IQR 57-76 years), the median tumor size was 4.4 cm (IQR 2.5-7.0 cm), and most common site of disease was the breast (59%). Recurrence was identified in 66% (44% LR and/or 41% DM), with a median follow up of 26.5 months (IQR 12-60 months). The 5-year OS was estimated at 50%, LRFS at 47%, and DMFS at 50%. There was no significant difference in LR, DM, or OS between the subtypes. Age < 65 years and administration of radiotherapy (RT) were significantly associated with lower LR rates (HR 0.560, 95% CI 0.3373-0.840, p = 0.005 and HR 0.421, 95% CI 0.225-0.790, p = 0.007, respectively), however no prognostic factors were identified for development of DM. Development of DM, but not LR (p = 0.052), was significantly associated with decreased OS (HR 6.486, 95% CI 2.939-14.318 p < 0.001).CONCLUSION: We found no significant difference in oncological outcome between the different cAS subtypes. OS remains relatively poor, and RT is associated with lower LR rates.

Subjects

Subjects :
Oncology
Surgery

Details

Language :
English
ISSN :
10689265
Volume :
30
Issue :
1
Database :
OpenAIRE
Journal :
Annals of Surgical Oncology
Accession number :
edsair.doi.dedup.....d5482a781904b6e575a9fa82c78a0696
Full Text :
https://doi.org/10.1245/s10434-022-12601-1