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The effect of loteprednol suspension eye drops after corneal transplantation
- Source :
- BMC Ophthalmology, Vol 21, Iss 1, Pp 1-8 (2021), BMC Ophthalmology
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- Background To compare the effect of loteprednol suspension eye drops after corneal transplantation with the effect of prednisolone acetate eye drops. Methods A total of 234 patients (234 eyes) who underwent penetrating keratoplasty (PKP) and lamellar keratoplasty (LKP) were retrospectively included. Patients who received 1 % prednisolone acetate eye drops were defined as 1 % prednisolone acetate eye drop group (n = 96), and patients who received 0.5 % loteprednol suspension eye drops were defined as 0.5 % loteprednol suspension eye drop group (n = 138). Results 35 cases in 1 % prednisolone acetate eye drops group and 27 cases in 0.5 % loteprednol suspension eye drops group developed corticosteroid-induced ocular hypertension, and were defined as prednisolone acetate group and loteprednol group. No significant differences were observed in the average intraocular pressure (IOP) at 1 week, 1 month, 3 months or 12 months postoperatively. There were significant differences in the average IOP between the two groups at 6 months postoperatively (P = 0.001). There were no significant differences in the average best corrected visual acuity (BCVA) at 1, 3 and 12 months postoperatively between two groups. The average 6-month postoperative BCVA was significantly higher in the prednisolone acetate group than the loteprednol group (P P > 0.05). Conclusions 0.5 % loteprednol suspension eye drops may be considered for long-term use after corneal transplantation.
- Subjects :
- Intraocular pressure
medicine.medical_specialty
genetic structures
Prednisolone acetate
Corticosteroid-induced ocular hypertension
medicine.medical_treatment
1 % prednisolone acetate eye drops
Ocular hypertension
Lamellar keratoplasty
Tonometry, Ocular
03 medical and health sciences
0302 clinical medicine
Ophthalmology
medicine
Humans
Corneal transplantation
Retrospective Studies
Best corrected visual acuity
0.5 % loteprednol suspension eye drops
business.industry
Loteprednol Etabonate
Eye drop
General Medicine
RE1-994
medicine.disease
eye diseases
Loteprednol
030221 ophthalmology & optometry
sense organs
Ophthalmic Solutions
business
Keratoplasty, Penetrating
030217 neurology & neurosurgery
Research Article
medicine.drug
Subjects
Details
- ISSN :
- 14712415
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- BMC Ophthalmology
- Accession number :
- edsair.doi.dedup.....d58724837e78e54a9e1a24cdec9e5513