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The use of chinese herb medicine in experimental radiotherapy
- Source :
- International Journal of Radiation Oncology*Biology*Physics. 16:347-352
- Publication Year :
- 1989
- Publisher :
- Elsevier BV, 1989.
-
Abstract
- Extracts from a group of destagnative herbs, 764-1, and the effective chemical, 764-3, were tested by an in vitro experiment using a HeLa-S3 cell line. Under aerobic conditions, the shoulder of the cell survival curve diminished or disappeared according to the different doses of 764-1 used, but no change in slope was observed. In nitrogen, when the dose of 764-1 increased to 20 mg/ml (ID20), besides the disappearance of the shoulder, the slope of the curve also showed changes at lower doses (4-8 Gy); up to 10-25 Gy the curve became more flattened. 764-3 showed almost a similar effect by mainly affecting the shoulder of the survival curve. At low drug doses a SER as high as 1.87 might be obtained under hypoxic condition. At the same time 764-1 was used in testing the effect on radiation lung damage. It was found that 764-1 could markedly inhibit the change of alveolar surfactant at 1 and 3 weeks after radiation. A wide field of investigation is thus spread out in front of us on radiosensitization and protection. Further studies on 764-3 are carried out.
- Subjects :
- Male
Radiation-Sensitizing Agents
Cancer Research
Herb medicine
Cell Survival
medicine.medical_treatment
Radiation-Protective Agents
In Vitro Techniques
Pharmacology
Mice
Pulmonary surfactant
medicine
Animals
Humans
Radiology, Nuclear Medicine and imaging
Respiratory system
Lung
Survival analysis
Radiation
business.industry
Pulmonary Surfactants
In vitro experiment
Radiation therapy
medicine.anatomical_structure
Oncology
Cell survival curve
Nuclear medicine
business
Drugs, Chinese Herbal
HeLa Cells
Subjects
Details
- ISSN :
- 03603016
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- International Journal of Radiation Oncology*Biology*Physics
- Accession number :
- edsair.doi.dedup.....d58d879eb39f91dcf20df8566e9630e4