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Molecular mechanisms of IgE mediated food allergy
- Source :
- International immunopharmacology. 13(4)
- Publication Year :
- 2012
-
Abstract
- The purpose of this review is to collate current knowledge and recent advances in molecular mechanism behind the immediate type hypersensitivity of foods. Food allergy is a growing concern of human health in developed as well as developing countries now days. Food allergic reactions are mostly IgE mediated and also known as immediate type hypersensitivity or type I reaction. This review encompasses a wide range of molecular events during IgE mediated reactions like primary exposure of allergens, processing of allergens by antigen presenting cells, role of transcription factors like GATA-3, STAT-6, NF-AT, c-maf, c-kit and NF-κB, Treg cells, toll like receptors, cytokines and chemokines, class switch to IgE, FceR1 receptor, priming of IgE on mast cells or basophils, signaling events followed by secondary exposure of allergens, degranulation and release of mediators like leukotrienes, histamines, prostaglandins, β-hexosaminidase and ultimately anaphylaxis. This review may be helpful to beginners as well as experts working in the field of allergy and immunology because of the stepwise explanations of molecular mechanisms involved in IgE mediated reactions.
- Subjects :
- Allergy
Immunology
Antigen presentation
Immunoglobulin E
Cell Degranulation
chemistry.chemical_compound
Food allergy
medicine
Immunology and Allergy
Animals
Humans
Anaphylaxis
Pharmacology
Antigen Presentation
biology
Chemistry
FCER1
Toll-Like Receptors
Degranulation
Allergens
medicine.disease
Gene Expression Regulation
biology.protein
Cytokines
Inflammation Mediators
Histamine
Food Hypersensitivity
Signal Transduction
Transcription Factors
Subjects
Details
- ISSN :
- 18781705
- Volume :
- 13
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- International immunopharmacology
- Accession number :
- edsair.doi.dedup.....d59740b7b1da85387d2ef7ecc6f24877