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Effectiveness of lifestyle intervention in subgroups of obese infertile women

Authors :: Henk Groen
Eugenie M. Kaaijk
R. van Golde
Jolande A. Land
Carolien A.M. Koks
G.J.E. Oosterhuis
M. A. Q. Mutsaerts
A. M. van Oers
LIFEstyle Study Grp
B.W.J. Mol
F. J. Broekmans
Niels E. A. Vogel
Walter K. H. Kuchenbecker
Jaap M. Schierbeek
Denise A. M. Perquin
Annemieke Hoek
Jan M. Burggraaff
APH - Methodology
APH - Quality of Care
Obstetrics and Gynaecology
Amsterdam Reproduction & Development (AR&D)
Obstetrie & Gynaecologie
RS: GROW - R4 - Reproductive and Perinatal Medicine
MUMC+: MA Medische Staf Obstetrie Gynaecologie (9)
Neurology
Obstetrics and gynaecology
Methods in Medicines evaluation & Outcomes research (M2O)
Reproductive Origins of Adult Health and Disease (ROAHD)
Value, Affordability and Sustainability (VALUE)
Source :: Human reproduction (Oxford, England), 32(2), 482-2713. Oxford University Press, Human Reproduction, 31(12), 2704-2713. Oxford University Press, Human Reproduction, 31(12), 2704. Oxford University Press, Van Oers, A M, Groen, H, Mutsaerts, M A Q, Burggraaff, J M, Kuchenbecker, W K H, Perquin, D A M, Koks, C A M, Van Golde, R, Kaaijk, E M, Schierbeek, J M, Oosterhuis, G J E, Broekmans, F J, Vogel, N E A, Land, J A, Mol, B W J & Hoek, A 2016, ' Effectiveness of lifestyle intervention in subgroups of obese infertile women : A subgroup analysis of a RCT ', Human Reproduction, vol. 31, no. 12, pp. 2704-2713 . https://doi.org/10.1093/humrep/dew252
Publication Year :: 2016
Abstract: STUDY QUESTION: Do age, ovulatory status, severity of obesity and body fat distribution affect the effectiveness of lifestyle intervention in obese infertile women? SUMMARY ANSWER: We did not identify a subgroup in which lifestyle intervention increased the healthy live birth rate however it did increase the natural conception rate in anovulatory obese infertile women. WHAT IS KNOWN ALREADY: Obese women are at increased risk of infertility and are less likely to conceive after infertility treatment. We previously demonstrated that a 6-month lifestyle intervention preceding infertility treatment did not increase the rate of healthy live births (vaginal live birth of a healthy singleton at term) within 24 months of follow-up as compared to prompt infertility treatment in obese infertile women. Natural conceptions occurred more frequently in women who received a 6-month lifestyle intervention preceding infertility treatment. STUDY DESIGN, SIZE, DURATION: This is a secondary analysis of a multicentre RCT (randomized controlled trial), the LIFEstyle study. Between 2009 and 2012, 577 obese infertile women were randomly assigned to a 6-month lifestyle intervention followed by infertility treatment (intervention group) or to prompt infertility treatment (control group). Subgroups were predefined in the study protocol, based on frequently used cut-off values in the literature: age (≥36 or