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The Relationship Between Cognition and Cerebrovascular Reactivity: Implications for Task-Based fMRI
- Source :
- Frontiers in Physics, Vol 9 (2021)
- Publication Year :
- 2021
- Publisher :
- Frontiers Media SA, 2021.
-
Abstract
- Elucidating the brain regions and networks associated with cognitive processes has been the mainstay of task-based fMRI, under the assumption that BOLD signals are uncompromised by vascular function. This is despite the plethora of research highlighting BOLD modulations due to vascular changes induced by disease, drugs, and aging. On the other hand, BOLD fMRI-based assessment of cerebrovascular reactivity (CVR) is often used as an indicator of the brain's vascular health and has been shown to be strongly associated with cognitive function. This review paper considers the relationship between BOLD-based assessments of CVR, cognition and task-based fMRI. How the BOLD response reflects both CVR and neural activity, and how findings of altered CVR in disease and in normal physiology are associated with cognition and BOLD signal changes are discussed. These are pertinent considerations for fMRI applications aiming to understand the biological basis of cognition. Therefore, a discussion of how the acquisition of BOLD-based CVR can enhance our ability to map human brain function, with limitations and potential future directions, is presented.
- Subjects :
- cognition
genetic structures
Materials Science (miscellaneous)
Biophysics
General Physics and Astronomy
behavioral disciplines and activities
cerebrovascular reactivity
Task (project management)
Vascular health
03 medical and health sciences
Neural activity
0302 clinical medicine
Cerebrovascular reactivity
medicine
Physical and Theoretical Chemistry
Mathematical Physics
Bold response
caffeine
030304 developmental biology
multiple sclerois
0303 health sciences
aging
Cognition
Human brain
functional magnetic resonance imaging
lcsh:QC1-999
medicine.anatomical_structure
nervous system
Vascular function
Psychology
Neuroscience
lcsh:Physics
psychological phenomena and processes
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 2296424X
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Frontiers in Physics
- Accession number :
- edsair.doi.dedup.....d5abd06ee5a1bb1571a905eb1fa40e64
- Full Text :
- https://doi.org/10.3389/fphy.2021.645249