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The Two NF-κB Pathways Regulating Bacterial and WSSV Infection of Shrimp
- Source :
- Frontiers in Immunology, Frontiers in Immunology, Vol 10 (2019)
- Publication Year :
- 2019
- Publisher :
- Frontiers Media S.A., 2019.
-
Abstract
- The outbreak of diseases ordinarily results from the disruption of the balance and harmony between hosts and pathogens. Devoid of adaptive immunity, shrimp rely largely on the innate immune system to protect themselves from pathogenic infection. Two nuclear factor-κB (NF-κB) pathways, the Toll and immune deficiency (IMD) pathways, are generally regarded as the major regulators of the immune response in shrimp, which have been extensively studied over the years. Bacterial infection can be recognized by Toll and IMD pathways, which activate two NF-κB transcription factors, Dorsal and Relish, respectively, to eventually lead to boosting the expression of various antimicrobial peptides (AMPs). In response to white-spot-syndrome-virus (WSSV) infection, these two pathways appear to be subverted and hijacked to favor viral survival. In this review, the recent progress in elucidating microbial recognition, signal transduction, and effector regulation within both shrimp Toll and IMD pathways will be discussed. We will also highlight and discuss the similarities and differences between shrimps and their Drosophila or mammalian counterparts. Understanding the interplay between pathogens and shrimp NF-κB pathways may provide new opportunities for disease-prevention strategies in the future.
- Subjects :
- 0301 basic medicine
lcsh:Immunologic diseases. Allergy
NF-κB pathways
Antimicrobial peptides
Immunology
Review
Biology
Microbiology
Arthropod Proteins
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Immune system
White spot syndrome virus 1
IMD
Penaeidae
Toll-like receptor
Immunology and Allergy
Animals
Innate immune system
Bacteria
Effector
fungi
NF-kappa B
white spot syndrome virus (WSSV)
NF-κB
Acquired immune system
Shrimp
030104 developmental biology
chemistry
shrimp
lcsh:RC581-607
030215 immunology
Signal Transduction
Subjects
Details
- Language :
- English
- ISSN :
- 16643224
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Frontiers in Immunology
- Accession number :
- edsair.doi.dedup.....d5b14030600397e3bb86af10ce08cbb2