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Enhanced Efficient NIR Photothermal Therapy Using Pleurocidin NRC-03 Peptide-Conjugated Dopamine-Modified Reduced Graphene Oxide Nanocomposite
- Source :
- ACS Omega, Vol 4, Iss 2, Pp 3298-3305 (2019)
- Publication Year :
- 2019
- Publisher :
- American Chemical Society, 2019.
-
Abstract
- Breast cancer remains the leading cause of morbidity and mortality among women. Therefore, there is an urgent need to develop effective treatments for breast cancer. Peptide-based therapies have been applied to treat various diseases, particularly cancer. Peptides that exhibit antimicrobial properties have recently been found to inactivate a wide range of cancer cells. However, some peptides degrade quickly in biological systems. Therefore, peptide-based nanotherapeutic approaches for cancer have been widely studied but are still in the early stages of research. The objective of this study is to synthesize a nanocomposite, NRC-03 peptide conjugated to polydopamine (pDA)-modified reduced graphene oxide (rGO), to facilitate the use of near-infrared light-activatable photothermal therapy to destroy breast tumor cells. The results show that immobilizing NRC-03 on the surface of dopamine-modified rGO can increase the stability of the NRC-03 peptide in a biological system. Furthermore, a burst release of the NR...
Details
- Language :
- English
- ISSN :
- 24701343
- Volume :
- 4
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- ACS Omega
- Accession number :
- edsair.doi.dedup.....d5b51d5151a06faa1b808cdf0c144abb