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Hepatoprotective effects of polyprenols from Ginkgo biloba L. leaves on CCl4-induced hepatotoxicity in rats
Hepatoprotective effects of polyprenols from Ginkgo biloba L. leaves on CCl4-induced hepatotoxicity in rats
- Source :
- Fitoterapia. 82(6)
- Publication Year :
- 2011
-
Abstract
- The hepatoprotective effects of polyprenols from Ginkgo biloba L. leaves were evaluated against carbon tetrachloride induced hepatic damage in Sprague–Dawley rats. The elevated levels of serum ALT, AST, ALP, ALB, TP, HA, LN, TG, and CHO were restored towards normalization significantly by GBP in a dose dependent manner. The biochemical observations were supplemented with histopathological examination of rat liver sections. Meanwhile, GBP also produced a significant and dose-dependent reversal of CCl4-diminished activity of the antioxidant enzymes and reduced CCl4-elevated level of MDA. In general, the effects of GBP were not significantly different from those of the standard drug Essentiale.
- Subjects :
- Male
Antioxidant
medicine.medical_treatment
CCL4
Pharmacology
Pharmacognosy
digestive system
Antioxidants
Rats, Sprague-Dawley
chemistry.chemical_compound
Random Allocation
Hemiterpenes
Pentanols
Drug Discovery
medicine
Animals
Ginkgoales
Carbon Tetrachloride
biology
Ginkgo biloba
Plant Extracts
Liver Diseases
General Medicine
Essentiale
biology.organism_classification
Rats
Plant Leaves
chemistry
Biochemistry
Toxicity
Carbon tetrachloride
Female
Chemical and Drug Induced Liver Injury
Subjects
Details
- ISSN :
- 18736971
- Volume :
- 82
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Fitoterapia
- Accession number :
- edsair.doi.dedup.....d5b58692003f5c4ca265a17acfbe2688