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Hepatoprotective effects of polyprenols from Ginkgo biloba L. leaves on CCl4-induced hepatotoxicity in rats

Hepatoprotective effects of polyprenols from Ginkgo biloba L. leaves on CCl4-induced hepatotoxicity in rats

Authors :
Cheng-zhang Wang
Hai-tao Li
Jian-zhong Ye
Lan Yang
Source :
Fitoterapia. 82(6)
Publication Year :
2011

Abstract

The hepatoprotective effects of polyprenols from Ginkgo biloba L. leaves were evaluated against carbon tetrachloride induced hepatic damage in Sprague–Dawley rats. The elevated levels of serum ALT, AST, ALP, ALB, TP, HA, LN, TG, and CHO were restored towards normalization significantly by GBP in a dose dependent manner. The biochemical observations were supplemented with histopathological examination of rat liver sections. Meanwhile, GBP also produced a significant and dose-dependent reversal of CCl4-diminished activity of the antioxidant enzymes and reduced CCl4-elevated level of MDA. In general, the effects of GBP were not significantly different from those of the standard drug Essentiale.

Details

ISSN :
18736971
Volume :
82
Issue :
6
Database :
OpenAIRE
Journal :
Fitoterapia
Accession number :
edsair.doi.dedup.....d5b58692003f5c4ca265a17acfbe2688