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Increased risk of recurrent thrombosis in patients with essential thrombocythemia carrying the homozygous JAK2 V617F mutation
- Source :
- Annals of Hematology, Annals of Hematology, Springer Verlag, 2009, 89 (2), pp.141-146. ⟨10.1007/s00277-009-0788-5⟩
- Publication Year :
- 2010
-
Abstract
- Evidence suggests that the JAK2 V617F mutation is associated with an increased risk of first thrombosis in patients with essential thrombocythemia (ET). Whether this mutation is also a risk factor for recurrent thrombosis is currently unknown. To investigate the impact of the JAK2 V617F mutation on the risk of recurrent thrombosis in patients with ET, we carried out a multicentre retrospective cohort study. We recruited 143 patients with previous arterial (64.4%) or venous major thrombosis (34.8%) or both (0.8%); 98 of them (68.5%) carried the mutation. Thrombosis recurred in 43 of the patients (30%); overall, after adjustment for sex, age, presence of vascular risk factors, and treatment after the first thrombosis, the presence of the JAK2 mutation did not predict recurrence (multivariable hazard ratio, HR, 0.88, 95% CI 0.46-1.68). Indeed, the individuals homozygous for the JAK2 V617F (allele burden >50%) mutation had an increased risk of recurrence in comparison with wild-type patients (HR 6.15, 95% CI 1.51-24.92). In conclusion, a homozygous JAK2 V617F mutation is an independent risk factor for recurrent thrombosis in patients with ET. © Springer-Verlag 2009.
- Subjects :
- Adult
Male
medicine.medical_specialty
Essential thrombocythemia
030204 cardiovascular system & hematology
Gastroenterology
03 medical and health sciences
Young Adult
0302 clinical medicine
Risk Factors
MED/15 - MALATTIE DEL SANGUE
Internal medicine
hemic and lymphatic diseases
Medicine
Humans
Allele
Risk factor
JAK2 V617F mutation
Aged
Aged, 80 and over
Hematology
business.industry
Hazard ratio
essential thrombocythemia
essential thrombocythemia - jak2 v617f mutation - recurrent thrombosis
jak2 v617f mutation
recurrent thrombosis
Retrospective cohort study
Thrombosis
General Medicine
Janus Kinase 2
Middle Aged
medicine.disease
3. Good health
Surgery
030220 oncology & carcinogenesis
Mutation (genetic algorithm)
Mutation
Female
Recurrent thrombosi
Recurrent thrombosis
business
Thrombocythemia, Essential
Subjects
Details
- Language :
- English
- ISSN :
- 09395555 and 14320584
- Database :
- OpenAIRE
- Journal :
- Annals of Hematology, Annals of Hematology, Springer Verlag, 2009, 89 (2), pp.141-146. ⟨10.1007/s00277-009-0788-5⟩
- Accession number :
- edsair.doi.dedup.....d5e2313e39de7cb336c9f9c6db9af18e