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High-mannose Type Oligosaccharide-dependent Apoptosis in U937 Cells Induced by Pradimicin, a Mannose-binding Antibiotic
- Source :
- The Journal of Antibiotics. 52:449-454
- Publication Year :
- 1999
- Publisher :
- Japan Antibiotics Research Association, 1999.
-
Abstract
- Cell surface oligosaccharides play a role in a variety of biological events such as cell adhesion and signal transduction. We have shown that BMY-28864, a semi-synthetic analog of pradimicin, induced apoptosis of U937 cells which had been incubated with 1-deoxymannojirimycin, an inhibitor of mannosidase I. BMY-28864 was not cytotoxic to the cells which had been cultivated with other glycosidase inhibitors such as castanospermine and swainsonine. We thus propose that BMY-28864 induces apoptosis by acting on a specific mannose-rich oligosaccharide, presumably (Man)9(GlcNAc)2+.
- Subjects :
- Programmed cell death
Glycan
1-Deoxynojirimycin
Antifungal Agents
Oligosaccharides
Mannose
Apoptosis
Biology
chemistry.chemical_compound
Mannosidases
Drug Discovery
Humans
Cytotoxic T cell
Anthracyclines
Enzyme Inhibitors
Cell adhesion
Pharmacology
chemistry.chemical_classification
Antibiotics, Antineoplastic
Swainsonine
Mannose binding
Indolizines
U937 Cells
Oligosaccharide
Castanospermine
chemistry
Biochemistry
biology.protein
Fluorescein-5-isothiocyanate
Glucosidases
Subjects
Details
- ISSN :
- 18811469 and 00218820
- Volume :
- 52
- Database :
- OpenAIRE
- Journal :
- The Journal of Antibiotics
- Accession number :
- edsair.doi.dedup.....d5ea426949af91b9bd8d2a53706fdc70