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The prognostic value of retinal vessel analysis in primary open-angle glaucoma
- Source :
- Acta Ophthalmologica. 94:e474-e480
- Publication Year :
- 2016
- Publisher :
- Wiley, 2016.
-
Abstract
- Purpose To analyse a prognostic value of initial retinal vessel flicker response for the 3-year development of functional (visual field) and morphological (nerve fibre layer thickness) damage progression in primary open-angle glaucoma patients. Patients and methods Initially, 70 patients were recruited, and flicker response was measured by standardized procedure with the retinal vessel analyser (RVA). Ocular coherence tomography of retinal nerve fibre layer (OCT RNFL) and a visual field testing were performed at beginning and every 6 months for 3 years; 56 patients completed the study. Results No correlation was found between the progression of visual field (VF) mean defect and retinal nerve fibre layer (RNFL) thinning over 3 years on one and the maximal flicker reaction in arteries and veins on the other side (all p > 0.1). However, the calculated difference of examined parameters in the superior versus inferior retinal halves correlated significantly between the RNFL thinning and the initial maximal flicker response for arteries (p = 0.01) and veins (p = 0.003). Conclusion This longitudinal study did not find a general correlation between initial retinal vessel response to flicker light and the glaucoma damage progression measured by OCT and VF, hence limiting the relevance of the RVA device as a predictor of future glaucomatous damage.
- Subjects :
- Male
Retinal Ganglion Cells
medicine.medical_specialty
Intraocular pressure
genetic structures
Open angle glaucoma
Vision Disorders
Glaucoma
Diagnostic Techniques, Ophthalmological
Tonometry, Ocular
03 medical and health sciences
chemistry.chemical_compound
Nerve Fibers
0302 clinical medicine
Ophthalmology
medicine
Humans
Prospective Studies
Prospective cohort study
Intraocular Pressure
Aged
business.industry
Flicker
Retinal Vessels
Retinal
General Medicine
Middle Aged
Prognosis
medicine.disease
eye diseases
Visual field
Retinal vessel
chemistry
030221 ophthalmology & optometry
Visual Field Tests
Female
sense organs
Visual Fields
business
Glaucoma, Open-Angle
Photic Stimulation
Tomography, Optical Coherence
030217 neurology & neurosurgery
Follow-Up Studies
Subjects
Details
- ISSN :
- 1755375X
- Volume :
- 94
- Database :
- OpenAIRE
- Journal :
- Acta Ophthalmologica
- Accession number :
- edsair.doi.dedup.....d5f0f9512b06fa1f27a700a7c60d5609