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Analysis of lymph node metastasis in pancreatic neuroendocrine tumors (PNETs) based on the tumor size and hormonal production
- Source :
- Journal of Gastroenterology. 47:678-685
- Publication Year :
- 2012
- Publisher :
- Springer Science and Business Media LLC, 2012.
-
Abstract
- Because of the rarity and variety of pancreatic neuroendocrine tumors (PNETs), there have been few reports regarding the indication for lymph node dissection in patients with these tumors. This study aimed to evaluate the risk of lymph node metastasis of PNETs based on the tumor size and hormonal production.Data for a total of 66 patients who had PNETs resected at our department between 1987 and 2010 were retrospectively studied. The clinicopathological features, including the disease-specific survival rate, were assessed based on the status of lymph node metastasis at the time of initial surgical resection. Then the cut-off point of tumor size to predict lymph node metastasis was estimated.There were 12 patients (18%) with lymph node metastasis. The frequency of lymph node metastasis tended to be higher in gastrinomas than that in other tumors (43 vs. 15%; P = 0.08). The size of PNETs with lymph node metastasis was significantly larger than that of the PNETs without metastasis (P = 0.04). The postoperative survival rate in the PNET patients with lymph node metastasis was significantly lower than that in the patients without metastasis (P0.0001). Only 2 (8%) of 26 PNETs with a tumor size of15 mm had lymph node metastasis, and both of these were gastrinomas. On the other hand, 10 (25%) of the remaining 40 PNETs with a tumor size of ≥15 mm had lymph node metastasis. Notably, there were no PNETs with lymph node metastasis in 22 non-gastrinomas with a tumor size of15 mm.Non-gastrinomas with a tumor size of ≥15 mm and all gastrinomas would be an indication for pancreatectomy with lymph node dissection.
- Subjects :
- Adult
Male
Oncology
medicine.medical_specialty
Lymph node metastasis
Neuroendocrine tumors
Young Adult
Pancreatectomy
Internal medicine
medicine
Humans
In patient
Lymph node
Aged
Retrospective Studies
Tumor size
business.industry
Gastroenterology
Middle Aged
medicine.disease
Survival Analysis
Hormones
Pancreatic Neoplasms
Neuroendocrine Tumors
Dissection
medicine.anatomical_structure
Gastrinoma
Lymphatic Metastasis
Lymph Node Excision
Female
business
Hormone
Subjects
Details
- ISSN :
- 14355922 and 09441174
- Volume :
- 47
- Database :
- OpenAIRE
- Journal :
- Journal of Gastroenterology
- Accession number :
- edsair.doi.dedup.....d5faa482477c4ee0d6013517dc17e6c8