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Schistosoma mansoni: Migration potential of normal and radiation attenuated parasites in naive guinea pigs
- Source :
- Experimental Parasitology. 63:98-107
- Publication Year :
- 1987
- Publisher :
- Elsevier BV, 1987.
-
Abstract
- Compressed tissue autoradiography using [ 75 Se]selenomethionine labelled parasites has been used to investigate the migration potential of normal and radiation attenuated cercariae of Schistosoma mansoni in naive guinea pigs. By Day 14 after infection, 44% of normal parasites were detected as reduced silver foci in the liver; this value corresponded well with the number of liver parasites recovered by retrograde perfusion of the hepatic portal system on Day 42 (42% of the challenge). In contrast, cercariae subjected to 50 krad of gamma irradiation failed to migrate out of the skin. The migration capacity of 20 krad irradiated parasites was less severely affected in that about half of the challenge parasites reached the lungs, but virtually none moved to the liver. These data are discussed in relation to the kinetics of immunity induced in guinea pigs by infection or vaccination with normal or radiation attenuated parasites.
- Subjects :
- Time Factors
Movement
Guinea Pigs
Immunology
Schistosomiasis
Hepatic portal system
Andrology
Immunity
parasitic diseases
medicine
Retrograde perfusion
Animals
Helminths
Respiratory system
Lung
Skin
Schistosoma
biology
Schistosoma mansoni
General Medicine
biology.organism_classification
medicine.disease
Schistosomiasis mansoni
Infectious Diseases
medicine.anatomical_structure
Liver
Gamma Rays
Autoradiography
Immunization
Parasitology
Subjects
Details
- ISSN :
- 00144894
- Volume :
- 63
- Database :
- OpenAIRE
- Journal :
- Experimental Parasitology
- Accession number :
- edsair.doi.dedup.....d60191d72c938762ec73df0fcfc21d3a