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Schistosoma mansoni: Migration potential of normal and radiation attenuated parasites in naive guinea pigs

Authors :
Diane J. McLaren
Haruo Kamiya
Source :
Experimental Parasitology. 63:98-107
Publication Year :
1987
Publisher :
Elsevier BV, 1987.

Abstract

Compressed tissue autoradiography using [ 75 Se]selenomethionine labelled parasites has been used to investigate the migration potential of normal and radiation attenuated cercariae of Schistosoma mansoni in naive guinea pigs. By Day 14 after infection, 44% of normal parasites were detected as reduced silver foci in the liver; this value corresponded well with the number of liver parasites recovered by retrograde perfusion of the hepatic portal system on Day 42 (42% of the challenge). In contrast, cercariae subjected to 50 krad of gamma irradiation failed to migrate out of the skin. The migration capacity of 20 krad irradiated parasites was less severely affected in that about half of the challenge parasites reached the lungs, but virtually none moved to the liver. These data are discussed in relation to the kinetics of immunity induced in guinea pigs by infection or vaccination with normal or radiation attenuated parasites.

Details

ISSN :
00144894
Volume :
63
Database :
OpenAIRE
Journal :
Experimental Parasitology
Accession number :
edsair.doi.dedup.....d60191d72c938762ec73df0fcfc21d3a